从欧洲七叶树果实中提取的生物活性皂苷。
Bioactive saponins from the fruits of Aesculus pavia L.
机构信息
Branch hospital in Fengxian of Shanghai No. 6 people's hospital, Shanghai 201400, PR China
出版信息
Fitoterapia. 2011 Oct;82(7):1106-9. doi: 10.1016/j.fitote.2011.07.004. Epub 2011 Jul 20.
Continued chemical investigation on the fruits of Aesculus pavia L. resulted in theisolation and identification of two new oleanolic acid saponins, namely vaccaroside A (1) andvaccaroside B (2). The isolated furostanol saponins were evaluated for cytotoxic activity againsthuman normal amniotic and human lung carcinoma cell lines using neutral red and MTT assays.In vitro experiments showed significant cytotoxicity in a dose dependent manner with IC₅₀ valuesin the range of 27.80-79.02 μM.
对七叶树果实的持续化学研究导致分离和鉴定了两种新的齐墩果酸皂苷，即卫矛苷 A（1）和卫矛苷 B（2）。用中性红和 MTT 测定法评估了分离得到的呋甾烷醇皂苷对人正常羊膜和人肺癌细胞系的细胞毒性活性。体外实验显示，在剂量依赖性方式下具有显著的细胞毒性，IC₅₀值范围为 27.80-79.02 μM。
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