Key Laboratory of Modern TCM Department of Pharmacognosy, China Pharmaceutical University, Nanjing, P R China.
Planta Med. 2010 Nov;76(16):1892-6. doi: 10.1055/s-0030-1250029. Epub 2010 Jun 24.
A new triterpenoid glycoside, designated harproside (1), and a new iridoid glycoside, named pagide (2), along with six known triterpenoids (3-8), were obtained from the tubers of Harpagophytum procumbens D. C. (devil's claw), and their structures were established through chemical methods and spectroscopic analyses. In an in vitro assay, the six triterpenoids showed anti-inflammatory activity. Compounds 3, 7, and 8 showed significant inhibitory activity against neutrophil respiratory burst stimulated by PMA, while compounds 4, 5, and 6 showed marginal inhibitory activity.
从蒺藜科植物 Harpagophytum procumbens D. C.（魔鬼爪）的块茎中分离得到一个新的三萜皂苷，命名为 harproside（1），以及一个新的环烯醚萜苷，命名为 pagide（2），此外还分离得到了 6 个已知的三萜（3-8）。通过化学方法和光谱分析确定了它们的结构。在体外试验中，这 6 个三萜类化合物表现出抗炎活性。化合物 3、7 和 8 对 PMA 刺激的中性粒细胞呼吸爆发具有显著的抑制活性，而化合物 4、5 和 6 则表现出轻微的抑制活性。
