Taype C A, Castro J C, Accinelli R A, Herrera-Velit P, Shaw M A, Espinoza J R
Molecular Biotechnology Unit, Laboratories for Research and Development (LID), Universidad Peruana Cayetano Heredia, Peru.
Infect Genet Evol. 2006 Sep;6(5):361-7. doi: 10.1016/j.meegid.2006.01.002. Epub 2006 Feb 7.
Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3'UTR polymorphisms of SLC11A1 and different clinical forms of TB. Analysis used 507 patients with pulmonary TB, 123 with extra pulmonary TB and 513 controls. INT4 and D543N showed allelic association with pulmonary TB (P=0.02 and 0.03 respectively). INT4-D543N-3'UTR haplotypes showed an association with pulmonary TB (P=0.03). No association of SLC11A1 with miliary TB was observed, and a possible association of D543N to the pleural form (P=0.08) was suggested. These results support association between SLC11A1 and TB, particularly to the common pulmonary form.
SLC11A1基因多态性与宿主对结核病的易感性有关。我们研究了SLC11A1基因的INT4、D543N和3'UTR多态性与不同临床类型结核病之间的关联。分析纳入了507例肺结核患者、123例肺外结核患者和513例对照。INT4和D543N与肺结核存在等位基因关联（P值分别为0.02和0.03）。INT4 - D543N - 3'UTR单倍型与肺结核存在关联（P = 0.03）。未观察到SLC11A1与粟粒性结核有关联，提示D543N可能与胸膜炎型结核有关联（P = 0.08）。这些结果支持SLC11A1与结核病之间的关联，尤其是与常见的肺结核类型有关。
