北京基因型结核分枝杆菌感染与印度尼西亚结核病患者SLC11A1/NRAMP1基因多态性有关。
Infection with Mycobacterium tuberculosis Beijing genotype strains is associated with polymorphisms in SLC11A1/NRAMP1 in Indonesian patients with tuberculosis.
作者信息
van Crevel Reinout, Parwati Ida, Sahiratmadja Edhyana, Marzuki Sangkot, Ottenhoff Tom H M, Netea Mihai G, van der Ven Andre, Nelwan Ronald H, van der Meer Jos W, Alisjahbana Bachti, van de Vosse Esther
机构信息
Department of Internal Medicine and Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
出版信息
J Infect Dis. 2009 Dec 1;200(11):1671-4. doi: 10.1086/648477.
Differences in host immune genes may predispose to tuberculosis caused by particular Mycobacterium tuberculosis genotypes. We examined this hypothesis in Indonesia by spoligotyping M. tuberculosis isolates recovered from 336 patients with pulmonary tuberculosis and typing the patients' SLC11A1 gene (formerly known as "NRAMP1"), which is involved in susceptibility to tuberculosis. The M. tuberculosis Beijing genotype, which comprised 29.8% of all isolates, was strongly associated with 2 polymorphisms in SLC11A1: the D543N G allele (odds ratio [OR], 2.15; P=.005) and the 3' untranslated region (3'UTR) insertion/insertion genotype (OR, 2.5; P=.001). This finding supports the hypothesis of coevolution of M. tuberculosis and the human immune system.
宿主免疫基因的差异可能使个体易患由特定结核分枝杆菌基因型引起的结核病。我们在印度尼西亚通过对从336例肺结核患者中分离出的结核分枝杆菌进行间隔寡核苷酸分型（spoligotyping），并对患者的溶质载体家族11成员A1基因（SLC11A1，以前称为“天然抗性相关巨噬细胞蛋白1”，即“NRAMP1”）进行分型，该基因与结核病易感性有关，从而检验了这一假设。结核分枝杆菌北京基因型占所有分离株的29.8%，与SLC11A1基因的2种多态性密切相关：D543N位点的G等位基因（优势比[OR]为2.15；P = 0.005）和3'非翻译区（3'UTR）插入/插入基因型（OR为2.5；P = 0.001）。这一发现支持了结核分枝杆菌与人类免疫系统共同进化的假设。
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