Mockenhaupt Frank P, Hamann Lutz, von Gaertner Christiane, Bedu-Addo George, von Kleinsorgen Cordula, Schumann Ralf R, Bienzle Ulrich
Institute of Tropical Medicine and International Health, Berlin, Germany.
J Infect Dis. 2006 Jul 15;194(2):184-8. doi: 10.1086/505152. Epub 2006 Jun 13.
Toll-like receptors (TLRs) are involved in recognition of and response to Plasmodium falciparum. In 304 primiparous Ghanaian women, we examined whether common TLR4 and TLR9 polymorphisms influence susceptibility to and manifestation of malaria during pregnancy. The TLR variants did not affect P. falciparum prevalence or parasite density. However, in P. falciparum-infected women, both the TLR4 Asp299Gly and the TLR9 T-1486C polymorphisms increased the risk of low birth weight in term infants 6-fold, and, additionally, TLR4 Asp299Gly increased the risk of maternal anemia 5-fold; preterm delivery was not associated with these TLR variants. These findings suggest that TLR4 and TLR9 play a role in the manifestation of malaria during pregnancy.
Toll样受体（TLRs）参与对恶性疟原虫的识别和反应。在304名加纳初产妇中，我们研究了常见的TLR4和TLR9基因多态性是否会影响孕期疟疾的易感性和表现。TLR变异体并未影响恶性疟原虫的流行率或寄生虫密度。然而，在感染恶性疟原虫的女性中，TLR4 Asp299Gly和TLR9 T-1486C基因多态性均使足月儿低出生体重风险增加了6倍，此外，TLR4 Asp299Gly使产妇贫血风险增加了5倍；早产与这些TLR变异体无关。这些发现表明，TLR4和TLR9在孕期疟疾的表现中发挥作用。
