Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang Province, PR China.
Joint Bone Spine. 2011 Mar;78(2):150-5. doi: 10.1016/j.jbspin.2010.04.011. Epub 2010 Jun 30.
Body mass index, a measure of relative weight, is increasingly recognized as an important risk factor for osteoarthritis, especially in weight bearing joints. The objective was to assess the association between body mass index and hip osteoarthritis susceptibility and investigate the difference between sex, study type and osteoarthritis definition.
We did electronic searches of Medline, Embase and Cochrane library from the commencement to December 2009. A meta-analysis and meta-regression was executed to quantitatively assess the strength of associations between body mass index and hip osteoarthritis risk. Study-specific incremental estimates were standardized to determine the risk associated with a 5 kg/m(2) increase in body mass index.
Fourteen epidemiological studies were included. Our study showed that body mass index was significantly positive associated with hip osteoarthritis risk. A 5-unit increase in body mass index was related to an increased risk of hip osteoarthritis (RR: 1.11; 95%CI: 1.07, 1.16). The magnitudes of associations were similar in women as compared with men (women, RR: 1.10; 95%CI: 1.05, 1.15; men, RR: 1.08; 95%CI: 1.04, 1.12; p > 0.05). The summary estimates were 1.12 (95%CI: 1.02, 1.24) in case-control studies and 1.11 (95%CI: 1.06, 1.16) in cohort studies (p > 0.05). Body mass index was positively associated with hip osteoarthritis defined by radiography and/or clinical symptom (RR: 1.04; 95%CI: 1.00, 1.07) and clinical surgery (RR: 1.16; 95%CI: 1.11, 1.22) with no significant difference (p > 0.05).
Increased body mass index contributes to a positive effect on susceptibility to hip osteoarthritis. Associations between body mass index and hip osteoarthritis risk do not vary by sex, study design or osteoarthritis definition.
体重指数是衡量相对体重的一种指标，它越来越被认为是骨关节炎的一个重要危险因素，尤其是在负重关节。本研究旨在评估体重指数与髋关节炎易感性之间的关系，并探讨性别、研究类型和骨关节炎定义之间的差异。
我们对 Medline、Embase 和 Cochrane 图书馆进行了电子检索，检索时间从建库开始至 2009 年 12 月。采用荟萃分析和荟萃回归定量评估体重指数与髋关节炎风险之间的关联强度。对特定研究的增量估计值进行了标准化，以确定体重指数每增加 5kg/m²所带来的相关风险。
共纳入 14 项流行病学研究。我们的研究表明，体重指数与髋关节炎风险呈显著正相关。体重指数每增加 5 个单位，髋关节炎的风险就会增加（RR：1.11；95%CI：1.07，1.16）。女性与男性相比，这种关联的程度相似（女性，RR：1.10；95%CI：1.05，1.15；男性，RR：1.08；95%CI：1.04，1.12；p＞0.05）。病例对照研究的汇总估计值为 1.12（95%CI：1.02，1.24），队列研究的汇总估计值为 1.11（95%CI：1.06，1.16）（p＞0.05）。体重指数与放射学和/或临床症状（RR：1.04；95%CI：1.00，1.07）以及临床手术（RR：1.16；95%CI：1.11，1.22）定义的髋关节炎呈正相关，差异无统计学意义（p＞0.05）。
体重指数的增加与髋关节炎易感性呈正相关。体重指数与髋关节炎风险之间的关联不受性别、研究设计或骨关节炎定义的影响。
