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聚乙二醇包覆的二氧化铈-氧化锆纳米颗粒通过激活自噬通量和清除活性氧来预防体重增加和肥胖相关器官损伤。

PEG-Coated Ceria-Zirconia Nanoparticle Prevent Weight Gain and Obesity-Related Organ Damage Through Autophagy Flux Activation and ROS Scavenging.

作者信息

Kim Eun Kyung, Hong Sang-Eun, Choi Yun Seok, Yu Seong-Lan, Kang Jaeku, Park Chang Gyo, Lee Hoi Young, Lee Sung-Ki, Lee Dong Chul, Hwang Won-Min, Yun Sung-Ro, Park Yohan, Park Moon Hyang, Lee Junguee, Yoon Kuk Ro, Lerman Lilach O, Yoon Se-Hee

机构信息

Division of Nephrology and Department of Internal Medicine, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Republic of Korea.

Department of Chemistry, Hannam University, Daejeon, Republic of Korea.

出版信息

Int J Nanomedicine. 2025 Jun 26;20:8305-8326. doi: 10.2147/IJN.S510541. eCollection 2025.

DOI:10.2147/IJN.S510541
PMID:40599398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12212437/
Abstract

PURPOSE: Obesity is becoming a global health problem that leads to serious complications. Despite numerous efforts to lose weight, achieving this goal is very difficult. Polyethylene glycol-coated ceria-zirconia nanoparticles (PEG-CZNPs) have attracted significant attention for their antioxidant properties, but they also have another valuable ability: restoring autophagy flux. In this study, we examined the therapeutic efficacy of PEG-CZNPs against obesity-induced organ complications and investigated the associated intracellular mechanisms. METHODS: Palmitate was used to establish a cellular model of obesity in HK-2 cells. An obesity mouse model was created by feeding a high-fat diet (HFD). PEG-CZNPs were successfully synthesized, and their physicochemical characteristics and antioxidant activity were confirmed. A concentration of 10 μg/mL PEG-CZNPs was used to treat HK-2 cells. For the in vivo experiment, PEG-CZNPs were administered intraperitoneally at a dose of 10 mg/kg (2 mL/kg), twice per week, with normal saline used as the vehicle control. Biochemical analysis, histological staining, and immunohistochemistry were performed on the liver, kidney and adipose tissue of the mice at 12 and 24 weeks after initiating the HFD. RESULTS: PEG-CZNPs successfully reduced lipid droplet accumulation palmitate-treated HK-2 cells by effectively restoring impaired autophagy flux. Reactive oxygen species (ROS), inflammation, and fibrotic changes caused by palmitate were also improved by PEG-CZNP treatment. In HFD-fed mice, PEG-CZNPs significantly reduced total body weight and the weights of the liver, kidney, and adipose tissue. They notably improved glucose tolerance and serum cholesterol levels while reducing tissue lipid accumulation. Additionally, PEG-CZNP treatment alleviated inflammatory cell infiltrations and fibrotic changes in the liver, kidney, and adipose tissue of HFD-fed mice. Autophagy flux was significantly enhanced, and ROS levels decreased in the tissue following PEG-CZNP treatment. CONCLUSION: PEG-CZNPs alleviated obesity-induced organ damage by decreasing intracellular lipid accumulation through the restoration of autophagy flux and ROS-scavenging activity.

摘要

目的：肥胖正成为一个导致严重并发症的全球健康问题。尽管人们为减肥付出了诸多努力，但实现这一目标却非常困难。聚乙二醇包覆的二氧化铈 - 氧化锆纳米颗粒（PEG - CZNPs）因其抗氧化特性而备受关注，不过它们还有另一项宝贵能力：恢复自噬通量。在本研究中，我们考察了PEG - CZNPs对肥胖诱导的器官并发症的治疗效果，并研究了相关的细胞内机制。 方法：使用棕榈酸酯在HK - 2细胞中建立肥胖细胞模型。通过喂食高脂饮食（HFD）创建肥胖小鼠模型。成功合成了PEG - CZNPs，并确认了其物理化学特性和抗氧化活性。使用浓度为10μg/mL的PEG - CZNPs处理HK - 2细胞。在体内实验中，以10mg/kg（2mL/kg）的剂量腹腔注射PEG - CZNPs，每周两次，以生理盐水作为载体对照。在开始高脂饮食后12周和24周，对小鼠的肝脏、肾脏和脂肪组织进行生化分析、组织学染色和免疫组织化学检测。 结果：PEG - CZNPs通过有效恢复受损的自噬通量，成功减少了棕榈酸酯处理的HK - 2细胞中的脂滴积累。PEG - CZNP处理还改善了由棕榈酸酯引起的活性氧（ROS）、炎症和纤维化变化。在喂食高脂饮食的小鼠中，PEG - CZNPs显著降低了总体重以及肝脏、肾脏和脂肪组织的重量。它们显著改善了葡萄糖耐量和血清胆固醇水平，同时减少了组织脂质积累。此外，PEG - CZNP处理减轻了喂食高脂饮食小鼠的肝脏、肾脏和脂肪组织中的炎性细胞浸润和纤维化变化。PEG - CZNP处理后，组织中的自噬通量显著增强，ROS水平降低。 结论：PEG - CZNPs通过恢复自噬通量和ROS清除活性来减少细胞内脂质积累，从而减轻肥胖诱导的器官损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/12212437/a6518a6357f7/IJN-20-8305-g0013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/12212437/13e4d10cd55c/IJN-20-8305-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/12212437/7fc0a6fe367b/IJN-20-8305-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/12212437/b057012808a9/IJN-20-8305-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/12212437/a54d39127108/IJN-20-8305-g0011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/12212437/a6518a6357f7/IJN-20-8305-g0013.jpg

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本文引用的文献

[1]
The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives.

Semin Cancer Biol. 2024-2

[2]
Role of TFEB-autophagy lysosomal pathway in palmitic acid induced renal tubular epithelial cell injury.

Biochem Biophys Res Commun. 2024-2-12

[3]
Pathophysiology of obesity and its associated diseases.

Acta Pharm Sin B. 2023-6

[4]
Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview.

Diabetes Metab Syndr Obes. 2023-6-14

[5]
Ceria-Based Therapeutic Antioxidants for Biomedical Applications.

Adv Mater. 2024-3

[6]
TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.

JCI Insight. 2023-2-22

[7]
Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds.

Biomed Pharmacother. 2022-11

[8]
A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on.

Metabolism. 2022-8

[9]
Ceria-Zirconia nanoparticles reduce intracellular globotriaosylceramide accumulation and attenuate kidney injury by enhancing the autophagy flux in cellular and animal models of Fabry disease.

J Nanobiotechnology. 2022-3-9

[10]
Impact of Exercise and Detraining during Childhood on Brown Adipose Tissue Whitening in Obesity.

Metabolites. 2021-10-1

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