营养、代谢综合征和肥胖的生物节律学方面。

Chronobiological aspects of nutrition, metabolic syndrome and obesity.

机构信息

Department of Physiology, University of Murcia, Spain.

出版信息

Adv Drug Deliv Rev. 2010 Jul 31;62(9-10):967-78. doi: 10.1016/j.addr.2010.05.005. Epub 2010 May 24.

DOI:10.1016/j.addr.2010.05.005

PMID:20580916

Abstract

The present review starts from the classical physiological and nutritional studies related with food intake control, digestion, transport and absorption of nutrients. It continues with studies related with the metabolism of adipose tissue, and finish with modern experiments in genetics and molecular biology - all from a fresh, chronobiological point of view. Obesity will be explained as a fault in the circadian system, as pathology associated with "chronodisruption". The main gaps in chronobiological research related to obesity will be also identified and chronobiological-based therapies will be proposed in order to allow the resetting of the circadian rhythm among obese subjects.

摘要

本综述从经典的与食物摄入控制、消化、营养物质运输和吸收有关的生理学和营养学研究开始。它接着涉及与脂肪组织代谢有关的研究，并以遗传学和分子生物学的现代实验结束——所有这些都是从一个新的、生理节奏学的角度来看待的。肥胖将被解释为生物钟系统的故障，即与“生物钟紊乱”相关的病理学。还将确定与肥胖相关的生理节奏学研究中的主要空白，并提出基于生理节奏学的治疗方法，以使肥胖者的生物钟节律得到重置。