生米净菌素产生菌链霉菌的基因组序列。
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.
机构信息
School of Life Science, Northeast Agricultural University, Harbin, China.
出版信息
J Bacteriol. 2010 Sep;192(17):4526-7. doi: 10.1128/JB.00596-10. Epub 2010 Jun 25.
Abstract
Streptomyces bingchenggensis is a soil-dwelling bacterium producing the commercially important anthelmintic macrolide milbemycins. Besides milbemycins, the insecticidal polyether antibiotic nanchangmycin and some other antibiotics have also been isolated from this strain. Here we report the complete genome sequence of S. bingchenggensis. The availability of the genome sequence of S. bingchenggensis should enable us to understand the biosynthesis of these structurally intricate antibiotics better and facilitate rational improvement of this strain to increase their titers.
摘要
兵城链霉菌是一种土壤栖息细菌，能够产生具有商业重要性的驱虫大环内酯米尔贝霉素。除了米尔贝霉素外，这种菌株还分离出了杀虫聚醚抗生素南昌霉素和其他一些抗生素。在这里，我们报告了兵城链霉菌的完整基因组序列。兵城链霉菌基因组序列的可用性应该使我们能够更好地理解这些结构复杂的抗生素的生物合成，并促进对该菌株进行合理的改进，以提高它们的产量。
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本文引用的文献
1
Three new milbemycin derivatives from Streptomyces bingchenggensis.
J Asian Nat Prod Res. 2009 Jul;11(7):597-603. doi: 10.1080/10286020902819897.
2
Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties.
J Antibiot (Tokyo). 2009 Sep;62(9):501-5. doi: 10.1038/ja.2009.60. Epub 2009 Jul 17.
3
Role of nsdA in negative regulation of antibiotic production and morphological differentiation in Streptomyces bingchengensis.
J Antibiot (Tokyo). 2009 Jun;62(6):309-13. doi: 10.1038/ja.2009.33. Epub 2009 May 15.
4
A novel macrolide compound from Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties.
J Antibiot (Tokyo). 2009 Apr;62(4):229-31. doi: 10.1038/ja.2009.14. Epub 2009 Mar 13.
5
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.
J Bacteriol. 2008 Jun;190(11):4050-60. doi: 10.1128/JB.00204-08. Epub 2008 Mar 28.
6
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J Antibiot (Tokyo). 2008 Jan;61(1):27-32. doi: 10.1038/ja.2008.105.
7
Further new milbemycin antibiotics from Streptomyces bingchenggensis. Fermentation, isolation, structural elucidation and biological activities.
J Antibiot (Tokyo). 2007 Oct;60(10):608-13. doi: 10.1038/ja.2007.78.
8
Two new beta-class milbemycins from streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties.
J Antibiot (Tokyo). 2007 Jun;60(6):351-6. doi: 10.1038/ja.2007.47.
9
Identifying bacterial genes and endosymbiont DNA with Glimmer.
Bioinformatics. 2007 Mar 15;23(6):673-9. doi: 10.1093/bioinformatics/btm009. Epub 2007 Jan 19.
10
A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin.
Chem Biol. 2003 May;10(5):431-41. doi: 10.1016/s1074-5521(03)00092-9.
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