不宁腿综合征的最新进展。
Update in restless legs syndrome.
机构信息
Department of Neurology, Division of Pulmonary/Critical Care, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA.
出版信息
Curr Opin Neurol. 2010 Aug;23(4):401-6. doi: 10.1097/WCO.0b013e32833bcdd8.
PURPOSE OF REVIEW
Although restless legs syndrome (RLS) is a disorder recognized in the medical literature since the 17th century, there have only recently been significant clinical and scientific advances in diagnosis, epidemiology and understanding the disorder, mainly due to the advent of dopaminergic treatment.
RECENT FINDINGS
Recent discoveries have uncovered the iron-dopamine connection in RLS and the basic dopaminergic pathology related to the RLS symptoms. These have led to new understanding of the morbidity of RLS and the many conditions associated with RLS, which have also supported new approaches to treatment. These developments are each briefly described here.
SUMMARY
Although there has been progress in understanding, diagnosing and treating RLS, it remains an underdiagnosed and undertreated condition severely impairing functioning of patients with moderate-to-severe disease. Much work is needed to improve on current, as well as other novel therapies.
目的综述
尽管不宁腿综合征（RLS）自 17 世纪以来就在医学文献中被认识，但直到最近，在诊断、流行病学和对该疾病的认识方面才取得了重大的临床和科学进展，这主要得益于多巴胺能治疗的出现。
最近的发现
最近的发现揭示了 RLS 中的铁-多巴胺连接以及与 RLS 症状相关的基本多巴胺病理学。这些发现导致了对 RLS 发病率和许多与 RLS 相关的疾病的新认识，也支持了新的治疗方法。这里简要描述了这些进展。
总结
尽管对 RLS 的理解、诊断和治疗已经取得了进展，但它仍然是一种被严重低估和治疗不足的疾病，严重影响了中重度疾病患者的功能。需要做更多的工作来改进现有的治疗方法，以及其他新的治疗方法。
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