Muntean Maria-Lucia, Sixel-Döring Friederike, Trenkwalder Claudia
Paracelsus Elena Klinik Kassel Germany.
Department of Neurosciences University of Medicine and Pharmacy Cluj-Napoca Romania.
Mov Disord Clin Pract. 2015 Jun 4;2(3):249-252. doi: 10.1002/mdc3.12165. eCollection 2015 Sep.
The frequency of RLS in Parkinson's disease (PD) patients has been reported to be between 10% and 26%. Several hypotheses have sought to link these two diseases; however, the pathophysiology of RLS in PD patients has yet to be completely defined. Many patients with idiopathic RLS have low serum ferritin levels, which negatively influence RLS symptomatology. Our objective was to investigate the role of iron deficiency in PD patients with and without RLS.
We consecutively included 42 PD inpatients undergoing pharmacological treatment. Patients with anemia, renal insufficiency, or polyneuropathy were excluded from the study. The control group consisted of 42 PD inpatients without RLS (PD-nonRLS), matched for age and severity of PD. RLS was diagnosed clinically according to diagnostic criteria. Serum ferritin levels were measured at admission for all patients.
Mean serum ferritin values were 142.20 ± 91.17 ng/dL for PD patients with RLS (PD+RLS) and 160.65 ± 142.57 ng/dL in PD-nonRLS ( = 0.704). There was no difference concerning the total dopaminergic dose (levodopa equivalent dose) between PD+RLS and PD-nonRLS patients (828.22 ± 389.02 vs. 775.32 ± 324.69 mg; = 0.501). The frequency of dopamine agonist (DA) use did not differ between the two groups ( = 0.306).
There were no significant differences in serum ferritin levels between PD+RLS and PD-nonRLS in our study. This suggests a different pathophysiology of RLS in PD patients, where iron deficiency is not necessarily observed. DA use was not found to be associated with the occurrence of RLS symptoms.
据报道，帕金森病（PD）患者中不安腿综合征（RLS）的发生率在10%至26%之间。有几种假说试图将这两种疾病联系起来；然而，PD患者中RLS的病理生理学尚未完全明确。许多特发性RLS患者血清铁蛋白水平较低，这对RLS症状有负面影响。我们的目的是研究缺铁在伴有和不伴有RLS的PD患者中的作用。
我们连续纳入了42名正在接受药物治疗的PD住院患者。患有贫血、肾功能不全或多发性神经病的患者被排除在研究之外。对照组由42名无RLS的PD住院患者（PD-非RLS）组成，根据年龄和PD严重程度进行匹配。RLS根据诊断标准进行临床诊断。所有患者入院时均测量血清铁蛋白水平。
伴有RLS的PD患者（PD+RLS）的平均血清铁蛋白值为142.20±91.17 ng/dL，PD-非RLS患者为160.65±142.57 ng/dL（P = 0.704）。PD+RLS和PD-非RLS患者之间的总多巴胺能剂量（左旋多巴等效剂量）没有差异（828.22±389.02 vs. 775.32±324.69 mg；P = 0.501）。两组之间多巴胺激动剂（DA）的使用频率没有差异（P = 0.306）。
在我们的研究中，PD+RLS和PD-非RLS患者的血清铁蛋白水平没有显著差异。这表明PD患者中RLS的病理生理学不同，不一定存在缺铁情况。未发现使用DA与RLS症状的发生有关。
