Thomson A H, Grant A C, Rodger R S, Hughes R L
Department of Medicine and Therapeutics, Stobhill General Hospital, Glasgow, Scotland.
DICP. 1991 Feb;25(2):127-9. doi: 10.1177/106002809102500203.
The dispositions and dose requirements for vancomycin and gentamicin were investigated in a 58-year-old man who was receiving long-term continuous venovenous hemofiltration. Estimates of clearance were obtained using a Bayesian parameter estimation program and stayed remarkably consistent throughout the therapy. Single daily doses of both vancomycin and gentamicin generally maintained the profiles for both drugs around the target ranges of peak 5-10 mg/L (gentamicin) and 25-40 mg/L (vancomycin) and trough less than 2 mg/L (gentamicin) and less than 10 mg/L (vancomycin).
对一名正在接受长期持续静脉-静脉血液滤过的58岁男性患者的万古霉素和庆大霉素的处置情况及剂量需求进行了研究。使用贝叶斯参数估计程序获得清除率估计值，并且在整个治疗过程中保持显著一致。万古霉素和庆大霉素的每日单次剂量通常使两种药物的血药浓度维持在目标范围左右，即庆大霉素峰值为5-10mg/L、万古霉素峰值为25-40mg/L，庆大霉素谷值低于2mg/L、万古霉素谷值低于10mg/L。
