Tollis M, Dietzschold B, Volia C B, Koprowski H
Istituto Superiore di Sanita-Viale Regina Elena, Rome, Italy.
Vaccine. 1991 Feb;9(2):134-6. doi: 10.1016/0264-410x(91)90270-g.
The ability of rabies virus ribonucleoprotein (RNP) to induce protective immunity against rabies and to prime for production of virus-neutralizing antibodies (VNA) was studied in monkeys. Following two immunizations with RNP, monkeys developed a strong anti-RNP response and were protected against a challenge infection with a lethal dose of street rabies virus. Monkeys that were primed with RNP and then immunized with a single dose of human diploid cell vaccine (HDCV) developed VNA titres comparable to the VNA titres in non-primed monkeys after a second HDCV immunization. The utility of rabies RNP for the pre-exposure prophylaxis of human rabies is discussed.
在猴子身上研究了狂犬病病毒核糖核蛋白（RNP）诱导抗狂犬病保护性免疫以及引发病毒中和抗体（VNA）产生的能力。用RNP进行两次免疫后，猴子产生了强烈的抗RNP反应，并对致死剂量的街狂犬病毒攻击感染具有抵抗力。先用RNP进行免疫，然后用单剂量人二倍体细胞疫苗（HDCV）进行免疫的猴子，在第二次HDCV免疫后产生的VNA滴度与未进行预免疫的猴子相当。文中讨论了狂犬病RNP在人类狂犬病暴露前预防中的应用。
