Weiss Elliot T, Geronemus Roy G
Laser & Skin Surgery Center of New York, New York, New York 10016, USA.
Lasers Surg Med. 2010 Jul;42(5):357-60. doi: 10.1002/lsm.20939.
Tuberous sclerosis (TS) is a well-described genetic disorder that is classically associated with up to hundreds of facial angiofibromas. Due to the progressive nature of the skin lesions and the early clinical presentation, a safe and effective technique for treating these disfiguring skin lesions is needed.
STUDY DESIGN/PATIENTS AND METHODS: We report a combinatorial technique for treating the angiofibromas of TS. We present a case series of three TS patients treated with this technique combining pinpoint electrosurgery, pulsed-dye laser treatment, and ablative fractional resurfacing (AFR).
In all presented cases, improvement in the number and appearance of facial angiofibromas and erythema is noted. No scarring or adverse events were reported.
The technique of electrosurgery, pulsed-dye laser treatment, and AFR represents a new and safe therapeutic option for treating facial angiofibromas associated with TS.
结节性硬化症（TS）是一种广为人知的遗传性疾病，典型表现为多达数百个面部血管纤维瘤。由于皮肤病变的进行性特征以及早期临床表现，需要一种安全有效的技术来治疗这些毁容性皮肤病变。
研究设计/患者与方法：我们报告了一种治疗TS血管纤维瘤的联合技术。我们展示了一个病例系列，三名TS患者采用了这种联合精确电外科手术、脉冲染料激光治疗和非剥脱性点阵激光换肤（AFR）的技术进行治疗。
在所有呈现的病例中，面部血管纤维瘤的数量和外观以及红斑均有改善。未报告有瘢痕形成或不良事件。
电外科手术、脉冲染料激光治疗和AFR技术是治疗与TS相关的面部血管纤维瘤的一种新的安全治疗选择。
