Bae-Harboe Yoon-Soo Cindy, Geronemus Roy G
Laser and Skin Surgery Center of New York, New York, New York.
Lasers Surg Med. 2013 Nov;45(9):555-7. doi: 10.1002/lsm.22189.
The angiofibromas of Tuberous sclerosis (TS) is well described manifestation. Due to the progressive nature of the skin lesion, a safe and effective technique for treating these disfiguring skin lesions is needed.
STUDY DESIGN/PATIENTS AND METHODS: We report a targeted topical and combination laser technique for treating the angiofibromas of TS in one patient. This includes treatment with topical sirolimus, pinpoint electrosurgery, pulsed-dye laser treatment, and ablative fractional resurfacing (AFR).
Improvement in the number and appearance of facial angiofibromas and erythema is noted, without scarring or adverse events.
The technique of targeted therapy with sirolimus with electrosurgery, pulsed dye laser treatment, and AFR represents an innovative, safe therapeutic option for treating facial angiofibromas associated with TS.
结节性硬化症（TS）的血管纤维瘤是一种已被充分描述的表现。由于皮肤病变的进行性发展，需要一种安全有效的技术来治疗这些毁容性皮肤病变。
研究设计/患者与方法：我们报告了一种针对一名结节性硬化症血管纤维瘤患者的靶向局部及联合激光技术。这包括局部使用西罗莫司治疗、点状电外科手术、脉冲染料激光治疗和非剥脱性分次激光皮肤重建术（AFR）。
面部血管纤维瘤的数量和外观以及红斑均有改善，且无瘢痕形成或不良事件。
西罗莫司联合电外科手术、脉冲染料激光治疗和非剥脱性分次激光皮肤重建术的靶向治疗技术是治疗与结节性硬化症相关的面部血管纤维瘤的一种创新、安全的治疗选择。
