好细胞，坏细胞：流式细胞术揭示了在 HIV 疾病中重要的 T 细胞亚群。
Good cell, bad cell: flow cytometry reveals T-cell subsets important in HIV disease.
机构信息
Immunotechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
出版信息
Cytometry A. 2010 Jul;77(7):614-22. doi: 10.1002/cyto.a.20905.
Abstract
Flow cytometry is a key technology in the study of HIV disease. In this article, we review various cellular markers that can be measured in the setting of pathogenesis or vaccination studies, including markers of activation, differentiation, senescence, immune suppression, and function. In addition, we discuss important considerations for making these measurements. Finally, we examine how flow cytometry studies have taught researchers about the disease process, and the potential for flow cytometry technology to guide treatment decisions and evaluate vaccine candidates in the future.
摘要
流式细胞术是研究 HIV 疾病的关键技术。本文综述了在发病机制或疫苗研究中可测量的各种细胞标志物，包括激活、分化、衰老、免疫抑制和功能标志物。此外，我们还讨论了进行这些测量的重要注意事项。最后，我们研究了流式细胞术研究如何帮助研究人员了解疾病过程，以及流式细胞术技术在未来指导治疗决策和评估疫苗候选物的潜力。
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