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孤立性结膜髓系肉瘤作为急性白血病的首发体征

Isolated conjunctival myeloid sarcoma as a presenting sign of acute leukemia.

作者信息

Lo Wu-Ping, Kuo Chin-Liang, Kuo Ming-Tse, Fang Po-Chiung

机构信息

Department of Ophthalmology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

出版信息

Chang Gung Med J. 2010 May-Jun;33(3):334-7.

Abstract

Myeloid sarcoma is known as a tumor mass of myeloblasts or immature myeloid cells occurring in an extramedullary site. When ophthalmic areas are involved, it is usually located in the orbits and noted at or after the diagnosis of an underlying leukemia. We report a 38 year-old woman who had isolated conjunctival myeloid sarcoma without any other clinical signs and symptoms. Acute myeloid leukemia (AML) was diagnosed after a thorough examination. The image studies revealed no orbital or subcutaneous involvement. The patient had complete remission of AML after systemic chemotherapy. We reported this case to emphasize the unusual presentation of a conjunctival nodule of uncertain origin, particularly if it is salmon- pink and grows rapidly. The patient should undergo prompt evaluation for underlying hematological disease even if there are no ocular or systemic symptoms.

摘要

髓系肉瘤是指发生于髓外部位的成髓细胞或未成熟髓样细胞的肿瘤性肿块。当眼部受累时,通常位于眼眶,且在潜在白血病诊断时或之后被发现。我们报告一名38岁女性,她患有孤立性结膜髓系肉瘤,无任何其他临床体征和症状。经过全面检查后诊断为急性髓系白血病。影像学检查未发现眼眶或皮下受累。患者经全身化疗后急性髓系白血病完全缓解。我们报告此病例以强调起源不明的结膜结节的不寻常表现,特别是如果它呈鲑鱼粉红色且生长迅速。即使没有眼部或全身症状,患者也应接受潜在血液系统疾病的及时评估。

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