Plant Tissue Culture Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, P.O. CIMAP, Lucknow 226015, India.
Eur J Med Chem. 2010 Sep;45(9):4379-82. doi: 10.1016/j.ejmech.2010.06.006. Epub 2010 Jun 12.
A labdane diterpene dialdehyde was first time isolated from the chloroform extract of rhizomes of Curcuma amada. This compound exhibited antitubercular activity (MIC=500 microg/mL) against Mycobacterium tuberculosis H(37)Rv strain in BACTEC-460 assay. Two of its semisynthetic analogues also exhibited antitubercular activity at 250-500 microg/mL. It is the first report on isolation and antimycobacterial activity of this dialdehyde from C. amada.
一种 labdane 二萜二醛首次从莪术根茎的氯仿提取物中分离得到。该化合物在 BACTEC-460 测定中对结核分枝杆菌 H(37)Rv 株显示出抗结核活性（MIC=500μg/mL）。其两个半合成类似物也在 250-500μg/mL 的浓度下显示出抗结核活性。这是首次从莪术中分离出这种二醛并报告其抗分枝杆菌活性。
