Rodríguez Ileana I, Rodríguez Abimael D
Department of Chemistry, University of Puerto Rico, P.O. Box 23346, San Juan, Puerto Rico 00931-3346.
J Nat Prod. 2003 Jun;66(6):855-7. doi: 10.1021/np030052c.
In the course of our study to find novel antimycobacterial secondary metabolites from Caribbean gorgonian octocorals, we have isolated a new diterpene alkaloid, namely, homopseudopteroxazole (1), as a minor constituent of the hexane extract from the sea plume Pseudopterogorgia elisabethae. Its structure was deduced by interpretation of combined spectroscopic data, including extensive 1D and 2D NMR measurements, and NMR spectral comparisons with known amphilectane models. Biological screening studies indicate that homopseudopteroxazole (1) is a strong growth inhibitor of Mycobacterium tuberculosis H(37)Rv.
在我们从加勒比海柳珊瑚中寻找新型抗分枝杆菌次生代谢产物的研究过程中，我们从海羽软珊瑚（Pseudopterogorgia elisabethae）的己烷提取物中分离出一种新的二萜生物碱，即高假蕨唑（1），它是一种次要成分。通过对包括广泛的一维和二维核磁共振测量在内的综合光谱数据进行解释，并与已知的两性节松萝烷模型进行核磁共振光谱比较，推断出了其结构。生物筛选研究表明，高假蕨唑（1）是结核分枝杆菌H(37)Rv的强效生长抑制剂。
