从爱泼斯坦-巴尔病毒诱导的狨猴肿瘤建立的细胞系的特征。
Characteristics of cell lines established from Epstein-Barr virus induced marmoset tumors.
作者信息
Neubauer R H, Rabin H, Hopkins R F, Levy B M
出版信息
Primates Med. 1978;10:156-62.
The inoculation of a cotton-topped marmoset with B95-8 strain of EBV resulted in the induction of a multifocal lymphoma and lymphoblastoid cell lines were established from liver, spleen and mesenteric lymph node tumors. The cell lines were remarkably similar to each other with respect to the presence of EBV and its expression, the surface properties of the cells and their stability, and the functional products of the cells. Karyotypic examination of the cell lines revealed the common loss of a single chromosome. The slight differences noted in karyotypes suggest some divergence from a tumor stem cell and imply a clonal origin. Thus, EBV-induced lymphomas in cotton-topped marmosets resemble Burkitt's lymphoma in man.
用EBV的B95 - 8株接种棉顶狨猴，导致多灶性淋巴瘤的发生，并从肝脏、脾脏和肠系膜淋巴结肿瘤中建立了淋巴母细胞系。这些细胞系在EBV的存在及其表达、细胞的表面特性及其稳定性以及细胞的功能产物方面彼此非常相似。对这些细胞系的核型检查显示共同丢失了一条染色体。核型中 noted 的细微差异表明与肿瘤干细胞存在一些分歧，并暗示克隆起源。因此，棉顶狨猴中EBV诱导的淋巴瘤类似于人类的伯基特淋巴瘤。 （注：原文中“noted”翻译为“ noted”可能有误，推测应为“noted”，意为“注意到的”，翻译时根据推测进行了调整。）
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