Deinhardt F, Falk L, Wolfe L G, Paciga J, Johnson D
IARC Sci Publ (1971). 1975(11 Pt 2):161-8.
The response of cotton-topped (CT) or white-lipped (WL) marmosets, inoculated with material containing Epstein-Barr virus (EBV), was studied. Twenty-five marmosets inoculated with 10(6)-10(8) cells from human or simian EBV-carrying lymphoblastoid cell cultures developed no detectable clinical disease. Transitory antibody titres to VCA were detected in sera from several of these marmosets. Thirty-eight marmosets inoculated with P3 virus (10(9) particles) and seven marmosets inoculated with 10(5) infectious units of HR-1 virus likewise developed no recognizable clinical or haematological disease over several years of observation. Fourteen marmosets were inoculated with 10(2)-10(4) transforming units (TFU) of EBV strain B95-8; five of 11 animals inoculated with 10(3)-10(4) TFU of virus developed malignant lymphoma and died 31-110 days PI. Antibodies to one or more EBV-specified antigens were detected in sera from nine of the inoculated marmosets. EBV-carrying lymphoblastoid cell cultures were established from the spleen and lymph-nodes of one animal that died with malignant lymphoma and from another animal that died 19 days PI from undetermined causes.
研究了接种含爱泼斯坦 - 巴尔病毒（EBV）材料的棉顶狨（CT）或白唇狨（WL）的反应。25只接种了来自人或猿类携带EBV的淋巴母细胞培养物中10⁶ - 10⁸个细胞的狨猴未出现可检测到的临床疾病。其中几只狨猴的血清中检测到针对VCA的短暂抗体滴度。38只接种P3病毒（10⁹个颗粒）的狨猴和7只接种10⁵感染单位HR - 1病毒的狨猴在数年的观察中同样未出现可识别的临床或血液学疾病。14只狨猴接种了EBV B95 - 8株的10² - 10⁴转化单位（TFU）；接种10³ - 10⁴ TFU病毒的11只动物中有5只发生恶性淋巴瘤并在接种后31 - 110天死亡。在9只接种的狨猴血清中检测到针对一种或多种EBV特异性抗原的抗体。从一只死于恶性淋巴瘤的动物以及另一只接种后19天因不明原因死亡的动物的脾脏和淋巴结中建立了携带EBV的淋巴母细胞培养物。
