Dipartimento di Chimica G. Ciamician, Università di Bologna, via Selmi 2, 40126 Bologna, Italy.
Org Biomol Chem. 2010 Sep 7;8(17):3992-6. doi: 10.1039/c004873a. Epub 2010 Jun 28.
The addition of organolithium reagents to the trianglimine derived from (R,R)-1,2-diaminocyclohexane and terephthalaldehyde gave the corresponding trianglamine with complete stereocontrol and the R configuration of all six newly formed stereocenters. The structure of the hexaphenyl-substituted macrocycle was determined by X-ray crystallographic study. The new trianglamines were tested as ligands in enantioselective catalytic reactions.
将有机锂试剂加入到（R，R）-1，2-二氨基环己烷和对苯二甲醛衍生的三嗪啉中，得到了具有完全立体控制和所有六个新形成的手性中心均为 R 构型的相应三嗪啉。通过 X 射线晶体学研究确定了六苯基取代大环的结构。新的三嗪啉被用作手性催化反应中的配体进行测试。
