Genetic Epidemiology Unit Ee2173, Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Eur J Epidemiol. 2010 Aug;25(8):561-8. doi: 10.1007/s10654-010-9476-y. Epub 2010 Jun 29.
While type 2 diabetes is well-known to be associated with poorer cognitive performance, few studies have reported on the association of metabolic syndrome (MetS) and contributing factors, such as insulin-resistance (HOMA-IR), low adiponectin-, and high C-reactive protein (CRP)-levels. We studied whether these factors are related to cognitive function and which of the MetS components are independently associated. The study was embedded in an ongoing family-based cohort study in a Dutch population. All participants underwent physical examinations, biomedical measurements, and neuropsychological testing. Linear regression models were used to determine the association between MetS, HOMA-IR, adiponectin levels, CRP, and cognitive test scores. Cross-sectional analyses were performed in 1,898 subjects (mean age 48 years, 43% men). People with MetS had significantly higher HOMA-IR scores, lower adiponectin levels, and higher CRP levels. MetS and high HOMA-IR were associated with poorer executive function in women (P = 0.03 and P = 0.009). MetS and HOMA-IR are associated with poorer executive function in women.
虽然 2 型糖尿病与认知表现较差密切相关，但很少有研究报告代谢综合征 (MetS) 及其相关因素（如胰岛素抵抗 (HOMA-IR)、低脂联素和高 C 反应蛋白 (CRP) 水平）与认知功能的关系。我们研究了这些因素是否与认知功能有关，以及 MetS 的哪些成分与认知功能有关。该研究是在荷兰一个基于家庭的队列研究中进行的。所有参与者都接受了体格检查、生物医学测量和神经心理学测试。线性回归模型用于确定 MetS、HOMA-IR、脂联素水平、CRP 与认知测试分数之间的关系。横断面分析在 1898 名受试者（平均年龄 48 岁，43%为男性）中进行。患有 MetS 的人 HOMA-IR 评分较高，脂联素水平较低，CRP 水平较高。MetS 和高 HOMA-IR 与女性执行功能较差有关（P = 0.03 和 P = 0.009）。MetS 和 HOMA-IR 与女性的执行功能较差有关。
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