Chang Yi-Min, Lee Chia-Lin, Wang Jun-Sing
Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407219, Taiwan.
Intelligent Data Mining Laboratory, Department of Medical Research, Taichung Veterans General Hospital, Taichung 407219, Taiwan.
J Clin Med. 2024 Apr 27;13(9):2571. doi: 10.3390/jcm13092571.
Metabolic syndrome (MS) is a constellation of several cardiometabolic risk factors. We investigated sex disparity in the associations between MS and cognitive impairment using cross-sectional data from Taiwan Biobank. We determined the associations of MS and its five components with cognitive impairment (mini-mental state examination, MMSE < 24) and the five domains of MMSE using logistic regression analyses. A total of 7399 men and 11,546 women were included, and MS was significantly associated with cognitive impairment only in women (adjusted OR 1.48, 95% CI 1.29-1.71, = 0.001) (p for interaction 0.005). In women, the association with MS was significant in orientation (adjusted OR 1.21, 95% CI 1.07-1.37, = 0.003), memory (adjusted OR 1.12, 95% CI 1.01-1.25, = 0.034) and design copying (adjusted OR 1.41, 95% CI 1.23-1.62, = 0.001) ( value for interaction 0.039, 0.023, and 0.093, respectively). Among the components of MS, a large waist circumference (adjusted OR 1.25, 95% CI 1.08-1.46, = 0.003), high fasting glucose (adjusted OR 1.16, 95% CI 1.00-1.34, = 0.046), and low HDL cholesterol (adjusted OR 1.16, 95% CI 1.00-1.34, = 0.049) were significantly associated with cognitive impairment in women. Our findings suggest that sex has a significant influence on the association between MS and cognitive dysfunction, especially in orientation and memory.
代谢综合征（MS）是多种心血管代谢危险因素的集合。我们利用台湾生物银行的横断面数据，研究了MS与认知障碍之间关联的性别差异。我们使用逻辑回归分析确定了MS及其五个组成部分与认知障碍（简易精神状态检查表，MMSE<24）以及MMSE的五个领域之间的关联。共纳入7399名男性和11546名女性，且MS仅在女性中与认知障碍显著相关（校正比值比1.48，95%置信区间1.29 - 1.71，P = 0.001）（交互作用P值为0.005）。在女性中，MS与定向力（校正比值比1.21，95%置信区间1.07 - 1.37，P = 0.003）、记忆力（校正比值比1.12，95%置信区间1.01 - 1.25，P = 0.034）和图形临摹（校正比值比1.41，95%置信区间1.23 - 1.62，P = 0.001）显著相关（交互作用P值分别为0.039、0.023和0.093）。在MS的各个组成部分中，大腰围（校正比值比1.25，95%置信区间1.08 - 1.46，P = 0.003）、高空腹血糖（校正比值比1.16，95%置信区间1.00 - 1.34，P = 0.046）和低高密度脂蛋白胆固醇（校正比值比1.16，95%置信区间1.00 - 1.34，P = 0.049）在女性中与认知障碍显著相关。我们的研究结果表明，性别对MS与认知功能障碍之间的关联有显著影响，尤其是在定向力和记忆力方面。
