• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[硫酸化多糖及其抗凝活性（综述）]

[Sulfated polysaccharides and their anticoagulant activity (review)].

作者信息

Mestechkina N M, Shcherbukhin V D

出版信息

Prikl Biokhim Mikrobiol. 2010 May-Jun;46(3):291-8.

PMID:20586281
Abstract

Published data on the sulfated polysaccharides of various origins that display an anticoagulant activity are summarized and analyzed. The methods used for producing semisynthetic derivatives are considered. A key role of the polysaccharide structure in the mechanisms of specific interaction with various blood plasma proteinases is discussed. The effects of the content and location of sulfate groups in polysaccharides and their molecular weight on the degree of the studied activity are assessed.

摘要

总结并分析了已发表的关于具有抗凝活性的各种来源硫酸化多糖的数据。考虑了用于制备半合成衍生物的方法。讨论了多糖结构在与各种血浆蛋白酶特异性相互作用机制中的关键作用。评估了多糖中硫酸基团的含量和位置及其分子量对所研究活性程度的影响。

相似文献

1
[Sulfated polysaccharides and their anticoagulant activity (review)].[硫酸化多糖及其抗凝活性（综述）]
Prikl Biokhim Mikrobiol. 2010 May-Jun;46(3):291-8.
2
Structure-function relationship of anticoagulant and antithrombotic well-defined sulfated polysaccharides from marine invertebrates.来自海洋无脊椎动物的具有明确抗凝血和抗血栓形成作用的硫酸化多糖的结构-功能关系。
Adv Food Nutr Res. 2012;65:195-209. doi: 10.1016/B978-0-12-416003-3.00012-3.
3
[Anticoagulant activity of sulfated polysaccharides].[硫酸化多糖的抗凝血活性]
Eksp Klin Farmakol. 2006 Nov-Dec;69(6):51-62.
4
Effects of polysaccharides enriched in 2,4-disulfated fucose units on coagulation, thrombosis and bleeding. Practical and conceptual implications.富含 2,4-二硫酸岩藻糖基单元的多糖对凝血、血栓形成和出血的影响。实际和概念上的意义。
Thromb Haemost. 2009 Nov;102(5):829-36. doi: 10.1160/TH08-11-0773.
5
Review: an overview about the structure-function relationship of marine sulfated homopolysaccharides with regular chemical structures.综述：关于具有规则化学结构的海洋硫酸化同多糖结构-功能关系的概述。
Biopolymers. 2009 Aug;91(8):601-9. doi: 10.1002/bip.21200.
6
Searching for alternatives to heparin: sulfated fucans from marine invertebrates.寻找肝素的替代品：来自海洋无脊椎动物的硫酸化岩藻聚糖。
Trends Cardiovasc Med. 1999 Nov;9(8):225-32. doi: 10.1016/s1050-1738(00)00032-3.
7
Experimental study on anticoagulant and antiplatelet aggregation activity of a chemically sulfated marine polysaccharide YCP.一种化学硫酸化海洋多糖YCP的抗凝及抗血小板聚集活性的实验研究
Int J Biol Macromol. 2005 Sep 15;36(4):201-7. doi: 10.1016/j.ijbiomac.2005.06.003.
8
Anticoagulant motifs of marine sulfated glycans.海洋硫酸化聚糖的抗凝血基序
Glycoconj J. 2014 Jul;31(5):341-4. doi: 10.1007/s10719-014-9530-1. Epub 2014 May 20.
9
The structure-anticoagulant activity relationships of sulfated lacquer polysaccharide: effect of carboxyl group and position of sulfation.硫酸化漆多糖的结构-抗凝活性关系：羧基和硫酸化位置的影响
Int J Biol Macromol. 2005 Jul;36(1-2):9-15. doi: 10.1016/j.ijbiomac.2005.03.002.
10
A 2-sulfated, 3-linked alpha-L-galactan is an anticoagulant polysaccharide.一种2-O-硫酸化、3-连接的α-L-半乳聚糖是一种抗凝血多糖。
Carbohydr Res. 2002 Nov 19;337(21-23):2231-8. doi: 10.1016/s0008-6215(02)00215-x.

引用本文的文献

1
Ion-Exchange Resin/Carrageenan-Copper-Based Nanocomposite: Artificial Neural Network, Advanced Thermodynamic Profiling, and Anticoagulant Studies.离子交换树脂/卡拉胶基铜纳米复合材料：人工神经网络、先进热力学分析及抗凝研究
ACS Omega. 2024 May 20;9(22):23873-23891. doi: 10.1021/acsomega.4c01540. eCollection 2024 Jun 4.
2
Structural Elucidation of Glycosaminoglycans in the Tissue of Flounder and Isolation of Chondroitin Sulfate C.斜带石斑鱼组织中糖胺聚糖的结构解析及硫酸软骨素 C 的分离。
Mar Drugs. 2024 Apr 26;22(5):198. doi: 10.3390/md22050198.
3
Cellulose Sulfate Nanofibers for Enhanced Ammonium Removal.
用于增强铵去除的硫酸纤维素纳米纤维
Nanomaterials (Basel). 2024 Mar 12;14(6):507. doi: 10.3390/nano14060507.
4
Phytoremediation of Wastewater Containing Lead and Manganese Ions Using Algae.利用藻类对含铅和锰离子废水进行植物修复
Biology (Basel). 2023 May 26;12(6):773. doi: 10.3390/biology12060773.
5
Marine Bioactive Compounds Derived from Macroalgae as New Potential Players in Drug Delivery Systems: A Review.源自大型海藻的海洋生物活性化合物作为药物递送系统中的新潜在参与者：综述
Pharmaceutics. 2022 Aug 25;14(9):1781. doi: 10.3390/pharmaceutics14091781.
6
One-Step Preparative Separation of Fucoxanthin from Three Edible Brown Algae by Elution-Extrusion Countercurrent Chromatography.洗脱-挤压逆流色谱一步法从三种食用褐藻中制备分离岩藻黄质。
Mar Drugs. 2022 Apr 7;20(4):257. doi: 10.3390/md20040257.
7
Sulfation of arabinogalactan with sulfamic acid under homogeneous conditions in dimethylsulfoxide medium.在二甲基亚砜介质中，于均相条件下用氨基磺酸对阿拉伯半乳聚糖进行硫酸化。
Wood Sci Technol. 2021;55(6):1725-1744. doi: 10.1007/s00226-021-01341-2. Epub 2021 Oct 20.
8
The Potency of Seaweed Sulfated Polysaccharides for the Correction of Hemostasis Disorders in COVID-19.海藻硫酸多糖纠正 COVID-19 出血障碍的效力。
Molecules. 2021 Apr 29;26(9):2618. doi: 10.3390/molecules26092618.
9
The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica.新冠病毒刺突糖蛋白与来自裙带菜的岩藻半乳聚糖和硫酸化半乳糖甘露聚糖相互作用的结构-活性关系。
Int J Biol Macromol. 2020 Nov 15;163:1649-1658. doi: 10.1016/j.ijbiomac.2020.09.184. Epub 2020 Sep 24.
10
Sulfation modulates the targeting properties of hyaluronic acid to P-selectin and CD44.硫酸化调节透明质酸与 P 选择素和 CD44 的靶向特性。
ACS Biomater Sci Eng. 2020 Jun 8;6(6):3585-3598. doi: 10.1021/acsbiomaterials.0c00115. Epub 2020 May 4.