奥曲肽（SMS 201-995）对三名胰外瘘患者进餐刺激的胰腺分泌的影响。
Effect of octreotide (SMS 201-995) on meal-stimulated pancreatic secretion in three patients with external pancreatic fistula.
作者信息
Gullo L, Biliotti G, Pezzilli R, Di Stefano M, Ancona D
机构信息
Institute of Medicine and Gastroenterology, University of Bologna, Italy.
出版信息
Am J Gastroenterol. 1991 Jul;86(7):892-4.
Octreotide (SMS 201-995) is a long-acting somatostatin analogue that inhibits both basal and secretin-cholecystokinin-stimulated pancreatic secretion. This study assesses the effect of this compound on pancreatic secretion induced by ordinary meals. Three patients with stable secretion of pure pancreatic juice from high output pancreatic fistula were studied. In all three, meal ingestion caused a marked and prolonged increase in pancreatic juice flow, and in bicarbonate and protein output. The subcutaneous injection of 50 micrograms octreotide before meals almost totally prevented (by about 90%) this increase. The inhibitory effect of octreotide on postprandial pancreatic secretion appeared soon, and persisted for the duration of the study period (8 h).
奥曲肽（SMS 201-995）是一种长效生长抑素类似物，可抑制基础状态以及促胰液素-胆囊收缩素刺激引起的胰腺分泌。本研究评估了该化合物对普通餐食诱导的胰腺分泌的影响。研究了3例高流量胰瘘且胰液分泌稳定的患者。在所有3例患者中，进食均导致胰液流量、碳酸氢盐和蛋白质分泌显著且持续增加。餐前皮下注射50微克奥曲肽几乎完全阻止了（约90%）这种增加。奥曲肽对餐后胰腺分泌的抑制作用出现迅速，并在研究期间（8小时）持续存在。
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