Anand B S, Goodgame R, Graham D Y
Digestive Diseases Section, VA Medical Center, Houston, Texas.
Am J Gastroenterol. 1994 Feb;89(2):267-70.
The inhibitory effect of different drugs on pancreatic secretions was assessed in a patient with a posttraumatic pancreatic-cutaneous fistula. The various drugs examined were: pancreatic enzymes, cimetidine, verapamil, propantheline, acetazolamide, and somatostatin analog octreotide. Only fasting and octreotide reduced pancreatic secretion. The optimum dose of octreotide was 50 micrograms bid given subcutaneously; increasing the dose up to 100 micrograms tid had no additional benefit. A stable pancreatic-cutaneous fistula is an excellent model to assess the effect of different therapeutic measures on pancreatic secretion.
在一名创伤后胰瘘患者中评估了不同药物对胰腺分泌的抑制作用。所检测的各种药物包括：胰酶、西咪替丁、维拉帕米、溴丙胺太林、乙酰唑胺和生长抑素类似物奥曲肽。只有禁食和奥曲肽能减少胰腺分泌。奥曲肽的最佳剂量为皮下注射50微克，每日两次；将剂量增加至100微克，每日三次并无额外益处。稳定的胰瘘是评估不同治疗措施对胰腺分泌影响的理想模型。
