Stermer E, Levy N, Potasman I, Jaffe M, Boss J
Department of Gastroenterology, Bnei-Zion Medical Center, Technion Faculty of Medicine, Haifa, Israel.
Am J Gastroenterol. 1991 Jul;86(7):917-9.
A 16-yr-old girl presented with osteomyelitis and massive rectal bleeding. Colonoscopy revealed severe nonspecific colitis. Multiple laboratory investigations failed to disclose the etiology of either the bone or colon infections. Empiric treatment with corticosteroids and sulfasalazine resulted in only transient improvement. One month after discharge, her original symptoms recurred. Blood and pus cultures at this time yielded Brucella melitensis. After tetracycline treatment, the patient recovered. At 1-yr follow-up, she was found completely asymptomatic. Although osteomyelitis is a well-known manifestation of brucellosis, colitis related to this agent has so far not been described.
一名16岁女孩出现骨髓炎和大量直肠出血。结肠镜检查显示为严重的非特异性结肠炎。多项实验室检查未能揭示骨感染或结肠感染的病因。使用皮质类固醇和柳氮磺胺吡啶进行经验性治疗仅带来短暂改善。出院后一个月，她的原始症状复发。此时的血液和脓液培养检出了羊布鲁氏菌。四环素治疗后，患者康复。在1年的随访中，发现她完全无症状。虽然骨髓炎是布鲁氏菌病的一种众所周知的表现，但迄今为止尚未描述过与该病原体相关的结肠炎。
