Greater Miami Skin and Laser Center, Department of Dermatology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
Am J Clin Dermatol. 2010;11 Suppl 1:27-30. doi: 10.2165/1153418-S0-000000000-00000.
Nail psoriasis affects up to 90% of patients with psoriasis in their lifetime and is seen in 80% of patients with psoriatic arthritis. These changes of nail psoriasis often cause significant pain, psychological effects, and result in restrictions of daily activities. In patients with nail psoriasis, the choice of effective therapy is limited and depends on various factors, including the severity of the disease, the ability of patients to tolerate treatment, and their ability to pay (insurance) for what are, in some cases, expensive treatments. In recent years, biological therapies have proved effective in improving nail psoriasis, have generally proved to be well tolerated and require minimal patient monitoring. In the right situation, therefore, the use of biological agents is justified in patients with psoriatic nail disease.
指甲银屑病影响高达 90%的银屑病患者一生中，并在 80%的银屑病关节炎患者中可见。这些指甲银屑病的变化常常导致显著的疼痛、心理影响，并导致日常活动受限。在指甲银屑病患者中，有效的治疗选择是有限的，取决于多种因素，包括疾病的严重程度、患者对治疗的耐受能力以及他们对（某些情况下昂贵）治疗的支付能力（保险）。近年来，生物疗法已被证明可有效改善指甲银屑病，通常被证明具有良好的耐受性，并且需要对患者进行最少的监测。因此，在适当的情况下，生物制剂在银屑病指甲疾病患者中是合理的。
