Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Epidemiol Infect. 2011 Apr;139(4):494-504. doi: 10.1017/S0950268810001536. Epub 2010 Jun 29.
Susceptibility to vaccine-preventable diseases in Belgium in 2006 was estimated from a serum survey. Immunoglobulins against measles, mumps, rubella (MMR) and diphtheria at all available ages (1-65 years), and against tetanus in >40-year-olds, were measured by ELISA. Age-standardized overall seronegativity for MMR was low (3·9%, 8·0%, 10·4%, respectively). However, the World Health Organization's targets for measles elimination were not met in 5- to 24-year-olds and about 1 in 7 women at childbearing age (15-39 years) were seronegative for rubella. In adults >40 years, tetanus immunity (87·2%, >0·16 IU/ml) largely exceeded diphtheria immunity (20-45%, >0·1 IU/ml). Despite free universal vaccination against MMR for more than 20 years and against diphtheria and tetanus for almost 60 years, our study revealed specific age groups remaining at risk for infection with these pathogens.
2006 年，比利时通过血清调查估计了疫苗可预防疾病的易感性。采用 ELISA 法检测了所有可获得年龄（1-65 岁）的麻疹、腮腺炎、风疹（MMR）和白喉抗体，以及 40 岁以上人群的破伤风抗体。MMR 的血清学阴性率呈年龄标准化，整体较低（分别为 3.9%、8.0%、10.4%）。然而，5-24 岁人群并未达到世界卫生组织消除麻疹的目标，约 1/7 的育龄妇女（15-39 岁）对风疹呈血清阴性。40 岁以上人群中，破伤风免疫力（87.2%，>0.16 IU/ml）大大超过白喉免疫力（20-45%，>0.1 IU/ml）。尽管 20 多年来一直在实施针对 MMR 的免费普遍疫苗接种，近 60 年来一直在实施针对白喉和破伤风的疫苗接种，但我们的研究仍揭示了这些病原体感染风险持续存在的特定年龄组。
