Department of Virology,Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University,Merelbeke,Belgium.
Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University,Diepenbeek,Belgium.
Epidemiol Infect. 2019 Jan;147:e154. doi: 10.1017/S0950268819000487.
Cytomegalovirus (CMV) infection is endemic worldwide but its seroprevalence varies widely. The goal of this study was to estimate the age-specific seroprevalence of CMV infection in Belgium based on two cross-sectional serological datasets from 2002 and 2006. The seroprevalence was estimated relying on diagnostic test results based on cut-off values pre-specified by the manufacturers of the tests as well as relying on mixture models applied to continuous pathogen-specific immunoglobulin G antibody titre concentrations. The age-specific seroprevalence of hepatitis A virus (HAV), based on three Belgian cross-sectional serological datasets from 1993, 2002 and 2006, was used as a comparator since individuals acquire lifelong immunity upon recovery, implying an increasing seroprevalence with age. The age group weighted overall CMV seroprevalence derived from the mixture model was 32% (95% confidence interval (CI) 31-34%) in 2002 and 31% (95% CI 30-32%) in 2006. We demonstrated that CMV epidemiology differs from the immunizing infection HAV. This was the first large-scale study of CMV and HAV serial datasets in Belgium, estimating seroprevalence specified by age and birth cohort.
巨细胞病毒（CMV）感染在全球范围内流行，但血清流行率差异很大。本研究的目的是根据 2002 年和 2006 年的两项横断面血清学数据集，估计比利时特定年龄组巨细胞病毒感染的血清流行率。血清流行率是根据制造商预先指定的检测截止值的检测结果来估计的，也依赖于应用于连续病原体特异性免疫球蛋白 G 抗体浓度的混合模型。根据 1993 年、2002 年和 2006 年的三项比利时横断面血清学数据集，使用甲型肝炎病毒（HAV）的年龄特异性血清流行率作为比较，因为个体在恢复后获得终身免疫力，这意味着血清流行率随着年龄的增长而增加。混合模型得出的年龄组加权总体 CMV 血清流行率在 2002 年为 32%（95%置信区间[CI]31-34%），在 2006 年为 31%（95% CI 30-32%）。我们证明了 CMV 流行病学与免疫性感染 HAV 不同。这是在比利时进行的首次关于 CMV 和 HAV 系列数据集的大规模研究，估计了按年龄和出生队列指定的血清流行率。
