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经皮腔内血管成形术及支架置入术治疗颅内椎基底动脉粥样硬化性狭窄和闭塞的临床结果

Clinical results of percutaneous transluminal angioplasty and stenting for intracranial vertebrobasilar atherosclerotic stenoses and occlusions.

作者信息

Tsuura M, Terada T, Masuo O, Tsumoto T, Yamaga H, Itakura T, Matsumoto H, Hyoutani G, Hayashi S

机构信息

Department of Neurological Surgery, Minami Wakayama Medical Center, Wakayama; Japan.

出版信息

Interv Neuroradiol. 2004 Dec 24;10 Suppl 2(Suppl 2):21-5. doi: 10.1177/15910199040100S205. Epub 2008 May 15.

Abstract

Eighteen patients with intracranial vertebrobasilar stenosis and occlusion were treated by PTA or stenting. In 11 of 18 cases, only PTA was performed and in seven of 18 cases, we used stents. The mean stenosis before and after PTA/stenting was 82.8% and 22.3%, respectively. In 11 cases of PTA only, the stenotic rate decreased from 81.8% to 29.6%, while 85.0% of the stenotic rate remarkably reduced to 6.0% in seven cases of stenting. The 30 days morbidity and 30 days mortality rate were 5.5% and 5.5%, respectively. There was only one haemorrhagic complication (cerebellar haemorrhage) in cases of stenting, and no ischemic events during or after the procedures. Restenosis (more than 50% stenosis) occurred in four of 18 cases(22.2%) during mean followup period of 12 months. Two patients with VA occlusion before treatment, developed restenosis and reocclusion. Complete total occlusion seems to be a high-risk lesion and strict follow-up is required. In this study, PTA/stenting for intracranial vertebrobasilar artery stenosis or occlusion is an effective treatment, but strict indications may be required because procedure-related 30 days morbidity rate was 5.5% in addition to unclear natural history.

摘要

18例颅内椎基底动脉狭窄和闭塞患者接受了经皮腔内血管成形术(PTA)或支架置入术治疗。18例患者中,11例仅接受了PTA治疗,7例使用了支架。PTA/支架置入术前、后的平均狭窄率分别为82.8%和22.3%。仅接受PTA治疗的11例患者中,狭窄率从81.8%降至29.6%,而7例接受支架置入术的患者中,85.0%的狭窄率显著降至6.0%。30天发病率和30天死亡率分别为5.5%和5.5%。支架置入术病例中仅出现1例出血并发症(小脑出血),手术期间及术后均无缺血事件发生。在平均12个月的随访期内,18例患者中有4例(22.2%)发生再狭窄(狭窄超过50%)。2例治疗前椎动脉闭塞的患者出现再狭窄和再闭塞。完全闭塞似乎是一种高危病变,需要严格随访。在本研究中,PTA/支架置入术治疗颅内椎基底动脉狭窄或闭塞是一种有效的治疗方法,但由于30天手术相关发病率为5.5%且自然病史不明,可能需要严格掌握适应症。

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本文引用的文献

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Angioplasty for intracranial symptomatic vertebrobasilar ischemia.颅内症状性椎基底动脉缺血的血管成形术
Neurosurgery. 2002 Jul;51(1):23-7; discussion 27-9. doi: 10.1097/00006123-200207000-00004.

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