Iimura Yasushi, Tsutsumi Satoshi, Mitome Yumiko, Nonaka Yasuomi, Abe Yusuke, Yasumoto Yukimasa, Ito Masanori
Department of Neurological Surgery, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan.
Neurol Med Chir (Tokyo). 2010;50(6):482-4. doi: 10.2176/nmc.50.482.
A 6-month-old boy presented with a rare case of infected subdural hemorrhage manifesting as sustained fever and focal seizure. The boy had been well without contributory medical history. Physical examination found no neurological impairment with intact superficial appearance and soft fontanels. The parents denied recent head trauma or shaking injury. Blood examination was normal except for white blood cell count of 19200/microl and C-reactive protein level of 6.7 mg/dl. Bacterial culture of nasal swab, urine, stool, and venous blood samples was negative. Cerebrospinal fluid examination showed normal findings. Cranial computed tomography revealed an expansive subdural fluid collection in the right frontotemporal region. Magnetic resonance imaging showed the lesion as hypointense on T1- and hyperintense on T2-weighted images with intense enhancement of the outer membrane. The patient underwent burr-hole drainage, which identified the subdural hematoma encapsulated in a thick outer membrane and intermingled with pus material. Culture of the pus identified Escherichia coli. The patient received antibiotic therapy for 8 weeks that resulted in complete resolution of the infection. We assumed that preexisting subdural hematoma formed after minor head trauma was followed by hematogenous infection by E. coli. Infected subdural hematoma is possible in infants presenting with subdural hemorrhage with clinical symptoms of bacteremia.
一名6个月大的男婴出现了一例罕见的感染性硬膜下出血病例,表现为持续发热和局灶性癫痫发作。该男婴此前一直健康,无相关病史。体格检查未发现神经功能障碍,体表外观正常,囟门柔软。父母否认近期有头部外伤或摇晃损伤。血液检查除白细胞计数为19200/微升和C反应蛋白水平为6.7毫克/分升外均正常。鼻拭子、尿液、粪便和静脉血样本的细菌培养均为阴性。脑脊液检查结果正常。头颅计算机断层扫描显示右侧额颞区有一个扩大的硬膜下积液。磁共振成像显示该病变在T1加权像上呈低信号,在T2加权像上呈高信号,外膜有明显强化。患者接受了钻孔引流,发现硬膜下血肿被包裹在一层厚厚的外膜中,并与脓性物质混合。脓液培养鉴定为大肠杆菌。患者接受了8周的抗生素治疗,感染完全消退。我们推测,轻微头部外伤后先前存在的硬膜下血肿随后被大肠杆菌血行感染。有硬膜下出血且伴有菌血症临床症状的婴儿可能发生感染性硬膜下血肿。