Jacob Desmond, Shelton Ryan L, Applegate Brian E
Department of Biomedical Engineering, Texas A&M University, 337 Zachry Engineering Center, College Station, TX 77843, USA.
Opt Express. 2010 Jun 7;18(12):12399-410. doi: 10.1364/OE.18.012399.
We report the development of a two-color Fourier domain Pump-Probe Optical Coherence Tomography (PPOCT) system. Tissue phantom experiments to characterize the system performance demonstrated imaging depths in excess of 725 microm, nearly comparable to the base Optical Coherence Tomography system. PPOCT A-line rates were also demonstrated in excess of 1 kHz. The physical origin of the PPOCT signal was investigated with a series of experiments which revealed that the signal is a mixture of short and long lifetime component signals. The short lifetime component was attributed to transient absorption while the long lifetime component may be due to a mixture of transient absorption and thermal effects. Ex vivo images of porcine iris demonstrated the potential for imaging melanin in the eye, where cancer of the melanocytes is the most common form of eye cancer in adults.
我们报告了一种双色傅里叶域泵浦-探测光学相干断层扫描（PPOCT）系统的研发情况。用于表征系统性能的组织模型实验表明，成像深度超过725微米，几乎与基础光学相干断层扫描系统相当。PPOCT的A线速率也超过了1kHz。通过一系列实验研究了PPOCT信号的物理起源，结果表明该信号是短寿命和长寿命成分信号的混合。短寿命成分归因于瞬态吸收，而长寿命成分可能是瞬态吸收和热效应共同作用的结果。猪虹膜的离体图像显示了对眼中黑色素进行成像的潜力，黑色素细胞癌是成年人中最常见的眼癌形式。
