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皮肤滤泡中心淋巴瘤转化为弥漫性大B细胞淋巴瘤——一种不寻常的表现。

Transformation of a cutaneous follicle center lymphoma to a diffuse large B-cell lymphoma-an unusual presentation.

作者信息

Dias Coelho J, Diamantino F, Costa I, Farinha P, Gameiro P, Sebastião M, Baptista J

机构信息

Department of Dermatology, Centro Hospitalar Lisboa Central, EPE, Alameda Santo António dos Capuchos, 1169-050 Lisbon, Portugal.

出版信息

Case Rep Med. 2010;2010:296523. doi: 10.1155/2010/296523. Epub 2010 May 31.

DOI:10.1155/2010/296523
PMID:20589072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2879550/
Abstract

Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells in the skin. A definitive diagnosis is frequently delayed because of difficulties in interpretation of the histopathologic findings. It has an excellent prognosis with a 5-year survival over 95% and its risk of transformation has not been established. We describe a case report of man with a gastric diffuse large B-cell lymphoma (DLBCL) referred to our clinic because of nodules in the back that had gradually developed over a period of 10 years. A biopsy performed 3 years before was interpreted as reactive follicular hyperplasia. A new skin biopsy revealed a diffuse large B-cell lymphoma and immunoglobulin heavy chain gene rearrangements from the initial skin biopsy (PCBCL) and the DLBCL gastric biopsy were studied by polymerase chain reaction and an identical clonal rearrangement was detected which was highly suggestive of a transformation lymphoma.

摘要

原发性皮肤滤泡中心淋巴瘤（PCFCL）的特征是皮肤中滤泡中心细胞增殖。由于组织病理学结果的解读困难，明确诊断常常延迟。其预后良好，5年生存率超过95%，且其转化风险尚未明确。我们报告一例男性患者，因背部结节逐渐出现10年而转诊至我院。3年前进行的活检被诊断为反应性滤泡增生。再次进行皮肤活检显示为弥漫性大B细胞淋巴瘤，并通过聚合酶链反应研究了最初皮肤活检（PCBCL）和胃弥漫性大B细胞淋巴瘤（DLBCL）活检的免疫球蛋白重链基因重排，检测到相同的克隆重排，高度提示为转化型淋巴瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/b96ef6ffdab2/CRM2010-296523.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/dd5847c2e6a0/CRM2010-296523.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/416101525a33/CRM2010-296523.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/4f1d7e21d766/CRM2010-296523.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/c3cd46a47037/CRM2010-296523.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/d8cec6b27575/CRM2010-296523.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/b96ef6ffdab2/CRM2010-296523.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/dd5847c2e6a0/CRM2010-296523.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/416101525a33/CRM2010-296523.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/4f1d7e21d766/CRM2010-296523.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/c3cd46a47037/CRM2010-296523.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/d8cec6b27575/CRM2010-296523.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eab8/2879550/b96ef6ffdab2/CRM2010-296523.006.jpg

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J Clin Oncol. 2008 Nov 10;26(32):5165-9. doi: 10.1200/JCO.2008.16.0283. Epub 2008 Oct 6.
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Primary cutaneous follicle center lymphoma -'crosti lymphoma': what can we learn?原发性皮肤滤泡中心淋巴瘤——“克罗斯蒂淋巴瘤”：我们能学到什么？
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