Cerroni L, Kerl H
Department of Dermatology, University of Graz, Austria.
Leuk Lymphoma. 2001 Sep-Oct;42(5):891-900. doi: 10.3109/10428190109097708.
The exact classification of primary cutaneous follicle center cell lymphomas (FCCLs) has been the subject of ongoing debate. In the classification of cutaneous lymphomas proposed by the European Organization for Research and Treatment of Cancer (EORTC)-Cutaneous Lymphoma Project Group, cutaneous follicle center cell lymphoma (FCCL) is defined as a proliferation of centrocytes and centroblasts showing a diffuse pattern of growth in the great majority of cases, and presenting only rarely a true follicular pattern. CD10 and Bcl-2 are usually not expressed by neoplastic cells, and the t(14:18) is absent. By contrast, nodal follicular lymphoma is a tumor with a follicular pattern, characterized by the proliferation of CD10+, Bcl-2+ follicular cells, and by the presence of the t(14;18) in most cases. In this review we outline the clinicopathologic, phenotypic, and molecular features of primary cutaneous FCCL, reviewing criteria for diagnosis and differential diagnosis of this peculiar variant of cutaneous B-cell lymphoma.
原发性皮肤滤泡中心细胞淋巴瘤（FCCLs）的确切分类一直是持续争论的主题。在欧洲癌症研究与治疗组织（EORTC）皮肤淋巴瘤项目组提出的皮肤淋巴瘤分类中，皮肤滤泡中心细胞淋巴瘤（FCCL）被定义为在绝大多数病例中呈弥漫性生长模式的中心细胞和中心母细胞的增殖，仅极少数情况下呈现真正的滤泡模式。肿瘤细胞通常不表达CD10和Bcl-2，且不存在t(14:18)。相比之下，淋巴结滤泡性淋巴瘤是一种具有滤泡模式的肿瘤，其特征为CD10+、Bcl-2+滤泡细胞的增殖，且在大多数病例中存在t(14;18)。在本综述中，我们概述了原发性皮肤FCCL的临床病理、表型和分子特征，回顾了这种特殊类型皮肤B细胞淋巴瘤的诊断和鉴别诊断标准。
