镍催化炔基环烷酮的立体选择性环化反应构建双环或三环骨架的简便方法。

A facile construction of bi- or tricyclic skeletons by nickel-catalyzed stereoselective cyclization of alkynylcycloalkanone.

机构信息

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

出版信息

Org Lett. 2010 Aug 6;12(15):3494-7. doi: 10.1021/ol101329d.

PMID:20590086

Abstract

A nickel-catalyzed intramolecular cyclization of alkynylalkanone in the presence of Et(3)SiH using an NHC ligand produced various carbo- and heterocycles in a stereoselective manner. The reaction would proceed via formation of oxanickelacycle followed by sigma-bond metathesis with silane to give a bi- or tricyclic compound.

摘要

镍催化炔基丙炔酮在 NHC 配体存在下与三乙基硅烷的分子内环化反应以立体选择性的方式生成了各种碳环和杂环化合物。该反应通过形成氧镍环，然后与硅烷进行 sigma 键复分解反应来进行，得到双环或三环化合物。