通过炔烃的环化引发加成反应，实现高效的 Cu(I)催化的 N-杂环合成。
Highly efficient Cu(I)-catalyzed synthesis of N-heterocycles through a cyclization-triggered addition of alkynes.
机构信息
Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA.
出版信息
J Am Chem Soc. 2010 Jan 27;132(3):916-7. doi: 10.1021/ja908883n.
PMID:20041710
Abstract
An aminoalkyne (terminal or internal) and a terminal alkyne furnish functionalized five-, six-, and seven-membered N-heterocycles in excellent yields via a Cu(I)-catalyzed, one-pot, tandem hydroamination/alkynylation process.
摘要
一个氨炔（末端或内部）和一个末端炔烃通过 Cu(I)催化的一锅法串联氨化/炔基化反应，以优异的收率提供功能化的五、六和七元 N-杂环。
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