成瘾大脑中决策的神经调节。
Neuromodulation of decision-making in the addictive brain.
机构信息
Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Subst Use Misuse. 2010 Sep;45(11):1766-86. doi: 10.3109/10826084.2010.482434.
Abstract
Noninvasive brain stimulation of the dorsolateral prefrontal cortex with repetitive transcranial magnetic stimulation and transcranial direct current stimulation can modify decision-making behaviors in healthy subjects. The same type of noninvasive brain stimulation can suppress drug craving in substance user patients, who often display impaired decision-making behaviors. We discuss the implications of these studies for the cognitive neurosciences and their translational applications to the treatment of addictions. We propose a neurocognitive model that can account for our findings and suggests a promising therapeutic role of brain stimulation in the treatment of substance abuse and addictive behavior disorders.
摘要
经颅磁刺激和经颅直流电刺激对背外侧前额叶皮层的非侵入性脑刺激可以改变健康受试者的决策行为。同样类型的非侵入性脑刺激可以抑制物质使用患者的药物渴求，而这些患者通常表现出受损的决策行为。我们讨论了这些研究对认知神经科学的意义及其在成瘾治疗中的转化应用。我们提出了一个神经认知模型，可以解释我们的发现，并表明脑刺激在治疗物质滥用和成瘾行为障碍方面具有有前途的治疗作用。
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