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高频电刺激双侧伏隔核对吗啡诱导的条件性位置偏爱大鼠消退期和复燃期行为的影响

The Effect of High-Frequency Electrical Stimulation of Bilateral Nucleus Accumbens on the Behavior of Morphine-Induced Conditioned Place Preference Rats at Extinction and Reinstatement Phases.

作者信息

Yang Chunhui, Qiu Yiqing, Hu Xiaowu, Chen Jianchun, Wu Yina, Wu Xi

机构信息

Department of Neurosurgery, Changhai Hospital, Shanghai 200433, China.

出版信息

Evid Based Complement Alternat Med. 2020 Oct 12;2020:8232809. doi: 10.1155/2020/8232809. eCollection 2020.

DOI:10.1155/2020/8232809
PMID:33101448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7576340/
Abstract

OBJECTIVE

To explore the optimal time points for deep brain stimulation (DBS) on the treatment of morphine addiction and its possible mechanisms by investigating how high-frequency stimulation (HFS) in bilateral nucleus accumbens (NAc) at different time points influences the addictive behaviors of rats with drug addiction.

METHODS

The rats were randomly divided into extinction stimulation group ( = 20) and postextinction stimulation group ( = 20). Ten rats in the extinction stimulation group were treated using 120 Hz HFS during extinction stage while another 10 rats with pseudostimulation were served as control group. The CPP scores were evaluated at the second day after intervention, with total 9 sections accomplished. The CPP scores were evaluated at the second day of the intervention. In the postextinction stimulation group, 120 Hz HFS was intervened during the postextinction stage in 10 experimental rats and pseudostimulation was performed in 10 control rats. Stimulation was performed for 7 days continuously, and a small dose of morphine was administrated to induce relapse after the postextinction period.

RESULTS

During the extinction phase, CPP scores after HFS were significantly higher. During the postextinction phase, relapse CPP scores after HFS were dramatically lower.

CONCLUSION

HFS of bilateral NAc inhibits the extinction of addictive behavior during the extinction phase, and HFS during the postextinction period suppresses relapse of drug seeking behavior.

摘要

目的

通过研究不同时间点双侧伏隔核高频刺激（HFS）对药物成瘾大鼠成瘾行为的影响，探讨深部脑刺激（DBS）治疗吗啡成瘾的最佳时间点及其可能机制。

方法

将大鼠随机分为消退刺激组（n = 20）和消退后刺激组（n = 20）。消退刺激组10只大鼠在消退阶段采用120Hz HFS治疗，另10只进行假刺激的大鼠作为对照组。干预后第2天评估条件性位置偏爱（CPP）得分，共完成9个时间段。在干预的第2天评估CPP得分。在消退后刺激组中，10只实验大鼠在消退后阶段进行120Hz HFS干预，10只对照大鼠进行假刺激。连续刺激7天，在消退期后给予小剂量吗啡诱导复发。

结果

在消退阶段，HFS后CPP得分显著更高。在消退后阶段，HFS后复发CPP得分显著更低。

结论

双侧伏隔核HFS在消退阶段抑制成瘾行为的消退，而在消退后阶段HFS抑制觅药行为的复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/b06e95b74894/ECAM2020-8232809.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/9a1a79201f1d/ECAM2020-8232809.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/26410d165192/ECAM2020-8232809.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/56ab6a4bb678/ECAM2020-8232809.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/ce800a6bb132/ECAM2020-8232809.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/b06e95b74894/ECAM2020-8232809.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/9a1a79201f1d/ECAM2020-8232809.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/26410d165192/ECAM2020-8232809.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/56ab6a4bb678/ECAM2020-8232809.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/ce800a6bb132/ECAM2020-8232809.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30d5/7576340/b06e95b74894/ECAM2020-8232809.005.jpg

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