胞苷脱氨酶活性、C反应蛋白、组氨酸及红细胞沉降率作为银屑病关节炎疾病活动度的指标
Cytidine deaminase activity, C reactive protein, histidine, and erythrocyte sedimentation rate as measures of disease activity in psoriatic arthritis.
作者信息
Helliwell P S, Marchesoni A, Peters M, Platt R, Wright V
机构信息
University Department of Medicine, General Infirmary, Leeds.
出版信息
Ann Rheum Dis. 1991 Jun;50(6):362-5. doi: 10.1136/ard.50.6.362.
Abstract
Cytidine deaminase activity, C reactive protein, histidine, and erythrocyte sedimentation rate were measured in 36 subjects with psoriatic arthritis of varying disease duration and severity. Although cytidine deaminase activity may provide an integrated measure of synovial inflammation in rheumatoid arthritis, neutrophil accumulation in psoriatic plaques compromises this measure in psoriatic arthritis. Low histidine concentrations confirm that this amino acid provides a non-specific index of synovial inflammation. In psoriatic arthritis high C reactive protein concentrations seem to be associated with extensive joint destruction. In this study the erythrocyte sedimentation rate was found to be the best laboratory guide to clinical disease activity in psoriatic arthritis.
摘要
对36例患有不同病程和严重程度的银屑病关节炎患者进行了胞苷脱氨酶活性、C反应蛋白、组氨酸和红细胞沉降率的检测。虽然胞苷脱氨酶活性可能为类风湿关节炎的滑膜炎症提供一种综合测量指标，但银屑病斑块中的中性粒细胞聚集影响了该指标在银屑病关节炎中的测量。低组氨酸浓度证实这种氨基酸提供了滑膜炎症的非特异性指标。在银屑病关节炎中，高C反应蛋白浓度似乎与广泛的关节破坏有关。在本研究中，红细胞沉降率被发现是银屑病关节炎临床疾病活动度的最佳实验室指标。
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