颅内动脉瘤弹簧圈血管内栓塞的潜在机制。电血栓形成有多重要？
The Underlying Mechanisms of Endovascular Exclusion of Intracranial Aneurysms by Coils. How Important is Electrothrombosis?
作者信息
Henkes H, Brew S, Miloslavski E, Fischer S, Tavrovski I, Kühne D
机构信息
Klinik für Radiologie und Neuroradiologie, Alfried Krupp Krankenhaus, Essen, Germany -
出版信息
Interv Neuroradiol. 2003 Jun 30;9(2):127-40. doi: 10.1177/159101990300900202. Epub 2004 Oct 22.
Endovascular coil treatment of intracranial aneurysms is now widely accepted. We discuss some of the arguments for the relative roles of electrothrombosis, spontaneous thrombosis, mechanical filling, haemodynamic effects and surface properties in successful coil treatment. Despite an enormous body of literature, with many theories and much data, there is limited evidence for, or understanding of, the mechanisms by which coil treatment protects against aneurysm rupture. It seems likely that electrothrombosis plays no part.Dense packing is probably important in preventing recurrence. New technologies aiming to encourage endothelialisation and increased connective tissue formation appear promising.
颅内动脉瘤的血管内栓塞治疗目前已被广泛接受。我们讨论了电血栓形成、自发血栓形成、机械填充、血流动力学效应和表面特性在成功的栓塞治疗中的相对作用的一些观点。尽管有大量的文献，包含许多理论和大量数据，但对于栓塞治疗预防动脉瘤破裂的机制，证据有限，理解也不足。电血栓形成似乎不起作用。致密填塞可能对预防复发很重要。旨在促进内皮化和增加结缔组织形成的新技术似乎很有前景。
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