鸡气道中的α和β肾上腺素能受体
alpha and beta-adrenoceptors in chicken airways.
作者信息
Chand N, Eyre P
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Feb;19(2):353-9.
Isolated chicken bronchus (which had been partially contracted to carbachol) relaxes to isoproterenol and epinephrine but contracts weakly to phenylephrine. Propranolol (a beta-adrenoceptor blocker) antagonizes isoproterenol and reverses epinephrine-induced relaxations to feeble contractions. Phenylephrine-induced bronchoconstrictions and constrictions to epinephrine (in the presence of beta-blockade) were blocked by phentolamine. The results of this study showed the predominance of beta-)inhibitory) adrenoceptors and some alpha-(excitatory) adrenoceptors in the bronchus of the adult domestic fowl.
分离出的鸡支气管（已对卡巴胆碱产生部分收缩）对异丙肾上腺素和肾上腺素产生舒张反应，但对去氧肾上腺素产生微弱收缩。普萘洛尔（一种β-肾上腺素能受体阻滞剂）拮抗异丙肾上腺素，并使肾上腺素诱导的舒张反应逆转为微弱收缩。酚妥拉明可阻断去氧肾上腺素诱导的支气管收缩以及在β受体阻断存在时对肾上腺素的收缩反应。本研究结果表明，成年家禽支气管中β-（抑制性）肾上腺素能受体占优势，同时存在一些α-（兴奋性）肾上腺素能受体。
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