牛气道的药理学研究。组胺兴奋和抑制作用的证据。

Pharmacological study of bovine airways. Evidence for excitatory and inhibitory effects of histamine.

作者信息

Chand N, Eyre P, DeRoth L

出版信息

Can J Comp Med. 1979 Oct;43(4):384-91.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1320010/

Abstract

Bovine airway muscle contracts to carbachol greater than histamine greater than 2-methylhistamine greater than prostaglandin F2 alpha. Trachea of neonatal calves are more sensitive to histamine than those of older cattle. Partially contracted bovine airways relax to prostaglandins E1 and E2 greater than dopamine greater than phenylephrine greater than 4-methylhistamine greater than dimaprit. Histamine-induced airway constriction was incompletely blocked by mepyramine and the mepyramine-resistant component was blocked by atropine. After H1-receptor blockade, histamine-induced tracheobronchial relaxation was incompletely antagonized by metiamide and not blocked by propranolol or indomethacine, suggesting an atypical histamine receptor not associated with catecholamine or prostaglandin production.

摘要

牛气道平滑肌对卡巴胆碱的收缩反应大于组胺，大于2-甲基组胺，大于前列腺素F2α。新生犊牛的气管对组胺比成年牛更敏感。部分收缩的牛气道对前列腺素E1和E2的舒张反应大于多巴胺，大于去氧肾上腺素，大于4-甲基组胺，大于地马普明。组胺诱导的气道收缩被美吡拉敏不完全阻断，而美吡拉敏耐药成分被阿托品阻断。H1受体阻断后，组胺诱导的气管支气管舒张被甲硫咪胺不完全拮抗，且不被普萘洛尔或消炎痛阻断，提示存在一种与儿茶酚胺或前列腺素产生无关的非典型组胺受体。

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