Paediatric Department, Shahid Sadoughi University of Medical Sciences, Avicenna Street, Yazd 89168-56331, Iran.
Singapore Med J. 2010 May;51(5):440-5.
The present study was designed to compare two methods of vitamin D supplementation in infants: every two months as a routine vaccination versus a daily dose.
A randomised clinical trial was performed on 120 healthy breastfed infants between January and September 2007 in Yazd, Iran. The infants were randomly divided into three groups with different doses of vitamin D3 supplementation: 200 IU daily, 400 IU daily and a bolus of 50,000 IU every two months. A blood sample was taken and evaluated for 25-hydroxy vitamin D and calcium levels when the infants were six months old. The data was reported as the mean and standard deviation.
No significant differences were observed between the serum level of 25-hydroxy vitamin D in the groups administered with 200 IU and 400 IU vitamin D daily. However, the serum level of 25-hydroxy vitamin D reached significance in the third group (p is less than 0.001). All the blood calcium measured was below 11 mg/dl in the bolus group. A few complications such as diarrhoea and agitation, all of which were self-limited, were seen in the bolus group. No other significant side effects were reported in the other groups.
This study demonstrates that a bolus of 50,000 IU of vitamin D every two months with a routine child vaccination program provides the ideal serum level of vitamin D. This method produces no serious side effects and offers a highly convenient way to supply vitamin D, especially among non-compliant parents.
本研究旨在比较两种婴儿维生素 D 补充方法：常规疫苗接种每两个月一次与每日剂量。
2007 年 1 月至 9 月，在伊朗亚兹德对 120 名健康母乳喂养的婴儿进行了一项随机临床试验。婴儿被随机分为三组，接受不同剂量的维生素 D3 补充：每日 200IU、每日 400IU 和每两个月 50000IU 一剂。当婴儿 6 个月大时，采集血液样本并评估 25-羟维生素 D 和钙水平。数据以平均值和标准差报告。
每日给予 200IU 和 400IU 维生素 D 的两组血清 25-羟维生素 D 水平无显著差异。然而，第三组的血清 25-羟维生素 D 水平达到显著水平（p 小于 0.001）。在大剂量组，所有测量的血钙均低于 11mg/dl。大剂量组出现了一些并发症，如腹泻和激动，均为自限性。其他组未报告其他明显的副作用。
本研究表明，每两个月给予 50000IU 维生素 D 一剂，并与常规儿童疫苗接种计划相结合，可提供理想的血清维生素 D 水平。这种方法没有严重的副作用，并且提供了一种非常方便的维生素 D 供应方式，特别是在不遵守规定的父母中。
