Segura-Torres P, Portell-Cortés I, Morgado-Bernal I
Departament de Psicologia de la Salut, Facultat de Psicologia, Universitat Autonoma de Barcelona, Spain.
Behav Brain Res. 1991 Feb 28;42(2):161-7. doi: 10.1016/s0166-4328(05)80007-5.
Rats were trained in a two-way active avoidance task followed immediately by a lateral hypothalamic intracranial self-stimulation (ICSS) treatment, during 5 consecutive days. The effects of the number of ICSS trains allowed (0, 500, 2500 or 4500) were studied upon acquisition and long-term retention (LTR, 10 and 30 days). The number of ICSS trains administered and the number of avoidances at the last acquisition session (5th) showed a positive lineal relation, that is, the more number of ICSS trains, the more number of avoidances. The level of learning achieved during the 5th session was maintained after the LTR periods in all experimental groups. It is concluded that the number of ICSS trains could be a critical parameter in the facilitatory effect of lateral hypothalamic ICSS upon learning, and it is suggested that the facilitatory effect of post-training lateral hypothalamic ICSS might be due to the activation of general activatory neural systems.
大鼠在双向主动回避任务中接受训练，随后立即进行连续5天的下丘脑外侧颅内自我刺激（ICSS）治疗。研究了允许的ICSS训练次数（0、500、2500或4500）对习得和长期记忆（LTR，10天和30天）的影响。给予的ICSS训练次数与最后一次习得训练（第5次）时的回避次数呈正线性关系，即ICSS训练次数越多，回避次数越多。在所有实验组的LTR期后，第5次训练时达到的学习水平得以维持。得出的结论是，ICSS训练次数可能是下丘脑外侧ICSS对学习促进作用的关键参数，并表明训练后下丘脑外侧ICSS的促进作用可能是由于一般激活神经系统的激活。
