Massanés-Rotger E, Aldavert-Vera L, Segura-Torres P, Martí-Nicolovius M, Morgado-Bernal I
Departament de Psicobiologia i de Metodologia de les Ciències de la Salut, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Brain Res. 1998 Oct 19;808(2):220-31. doi: 10.1016/s0006-8993(98)00845-2.
To evaluate whether parafascicular nucleus (PF) is involved in the facilitative effect of lateral hypothalamic intracranial self-stimulation (LH-ICSS) on two-way active avoidance acquisition (5 sessions, 10 trials each, one daily) and long-term retention (10 days), rats were lesioned bilaterally at the PF and implanted with an electrode aimed at the LH to obtain ICSS behavior. After each acquisition session rats were allowed to self-administer 2500 trains of LH-ICSS. The main results were: (1) LH-ICSS facilitated the acquisition and retention of conditioning; (2) PF lesions impaired both acquisition and retention of two-way active avoidance; (3) there was a positive relationship between PF lesions size and learning disruption, and (4) LH-ICSS failed to facilitate learning when PF was lesioned. We concluded that the lesion size is a critical variable to evaluate the effects of PF lesions on learning and memory, and that LH-ICSS treatment may exert their effects through the PF nucleus or, at least, the integrity of PF is required for LH-ICSS to improve clearly the task.
为了评估束旁核（PF）是否参与下丘脑外侧颅内自我刺激（LH-ICSS）对双向主动回避学习（共5节，每天1节，每节10次试验）和长期记忆（10天）的促进作用，对大鼠双侧PF进行损伤，并植入电极以刺激LH从而获得ICSS行为。每次学习训练后，让大鼠自我给予2500次LH-ICSS刺激。主要结果如下：（1）LH-ICSS促进了条件反射的学习和记忆；（2）PF损伤损害了双向主动回避的学习和记忆；（3）PF损伤大小与学习障碍之间存在正相关；（4）PF损伤时，LH-ICSS未能促进学习。我们得出结论，损伤大小是评估PF损伤对学习和记忆影响的关键变量，并且LH-ICSS治疗可能通过PF核发挥作用，或者至少，LH-ICSS要明显改善任务需要PF的完整性。
