从青牛胆的根部分离得到细胞毒双苄基异喹啉生物碱。

Cytotoxic bisbenzylisoquinoline alkaloids from the roots of Cyclea racemosa.

机构信息

Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, No. 17, Duan 3, Renmin Nan Road, Chengdu, People's Republic of China.

出版信息

J Nat Prod. 2010 Jul 23;73(7):1288-93. doi: 10.1021/np1001863.

DOI:10.1021/np1001863

PMID:20593839

Abstract

Six new bisbenzylisoquinoline alkaloids, racemosidines A-C (1-3) and racemosinines A-C (4-6), and four known compounds were isolated from the roots of Cyclea racemosa. Compound 1 is the first bisbenzylisoquinoline alkaloid reported that has diphenyl ether bridges at C-11/C-7' and C-8/C-12' and a benzyl-phenyl ether bridge at C-7/C-11'. Structures and absolute configurations of 1-6 were established by interpretation of spectroscopic data and confirmed by X-ray crystallographic analysis of representative compounds. Compounds 1-3 exhibited significant cytotoxicity against HCT-8 and BEL-7402 tumor cells, and compound 1 was also cytotoxic against A2780 tumor cells.

摘要

从青牛胆的根部分离得到了六个新的双苄基异喹啉生物碱，分别为 racemosidines A-C（1-3）和 racemosinines A-C（4-6），以及四个已知化合物。化合物 1 是第一个报道的具有 C-11/C-7' 和 C-8/C-12' 处的二苯醚桥以及 C-7/C-11' 处的苄基-苯醚桥的双苄基异喹啉生物碱。通过对光谱数据的解释以及对代表性化合物的 X 射线晶体学分析，确定了 1-6 的结构和绝对构型。化合物 1-3 对 HCT-8 和 BEL-7402 肿瘤细胞表现出显著的细胞毒性，化合物 1 对 A2780 肿瘤细胞也具有细胞毒性。