从东京崖爬藤根中提取的双苄基异喹啉生物碱。

Bisbenzylisoquinoline alkaloids from the roots of cyclea tonkinensis.

作者信息

Wang Jian-Zhong, Liao Jing, Xu Wen-Long, Chen Xiao-Bing

机构信息

West China College of Pharmacy, Sichuan University, Chengdu, P. R. China.

出版信息

Planta Med. 2015 May;81(7):600-5. doi: 10.1055/s-0035-1545882. Epub 2015 Apr 9.

DOI:10.1055/s-0035-1545882

PMID:25856440

Abstract

Cissampentine A (1), an enantiomer of cissampentin, three new cycleatjehenine-type bisbenzylisoquinoline alkaloids, cissampentine B-D (2-4), and five known alkaloids were isolated from the roots of Cyclea tonkinensis. Their structures were established by interpretation of NMR, high-resolution ESI-MS data, and CD spectra. In vitro studies indicated that compounds 1 and 4 exhibited cytotoxicity against the HCT-8 tumor cell line (IC50 values of 8.97 and 9.73 µM, respectively), and compound 4 was also active against the Bel-7402 tumor cell line (IC50 value of 5.36 µM).

摘要

从东京崖爬藤的根部分离得到了锡生藤宁A（1），它是锡生藤宁的对映体，还有三种新的轮环藤宁型双苄基异喹啉生物碱，即锡生藤宁B - D（2 - 4），以及五种已知生物碱。通过对核磁共振（NMR）、高分辨率电喷雾电离质谱（ESI - MS）数据和圆二色光谱（CD）的解析确定了它们的结构。体外研究表明，化合物1和4对HCT - 8肿瘤细胞系具有细胞毒性（IC50值分别为8.97和9.73 μM），并且化合物4对Bel - 7402肿瘤细胞系也有活性（IC50值为5.36 μM）。