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从榕属植物中分离得到的细胞毒三萜生物碱。

Cytotoxic triterpenoid alkaloids from Buxus microphylla.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.

出版信息

J Nat Prod. 2009 Feb 27;72(2):308-11. doi: 10.1021/np800719h.

DOI:10.1021/np800719h

PMID:19133780

Abstract

Five new triterpenoid alkaloids, buxmicrophyllines E-I (1-5), and six known ones (6-11) were isolated from the leaves and stems of Buxus microphylla. The structures of compounds 1-5 were elucidated by NMR and MS spectroscopic analysis, and the relative stereochemistry of 5 was determined by single-crystal X-ray crystallography. Compounds 3 and 9 were cytotoxic against HepG2 cells, with IC(50) values of 0.89 and 0.78 microM, and compounds 2, 3, 7, 8, and 9 were cytotoxic against K562 cells, with IC(50) values of 2.95, 4.44, 1.70, 5.61, and 0.37 microM, respectively.

摘要

从榕属植物的叶和茎中分离得到五个新的三萜生物碱，即 buxmicrophyllines E-I（1-5），以及六个已知的化合物（6-11）。通过 NMR 和 MS 光谱分析阐明了化合物 1-5 的结构，并通过单晶 X 射线晶体学确定了 5 的相对立体化学。化合物 3 和 9 对 HepG2 细胞具有细胞毒性，IC(50)值分别为 0.89 和 0.78 microM，化合物 2、3、7、8 和 9 对 K562 细胞具有细胞毒性，IC(50)值分别为 2.95、4.44、1.70、5.61 和 0.37 microM。